Acid chlorides can be selectively reduced to their corresponding aldehydes using hydrogen gas in the presence of a partially deactivated palladium catalyst, known as the Rosenmund catalyst. This catalyst is prepared by depositing palladium (Pd) on barium sulfate (BaSO₄) and then poisoning it with additives such as 2,6-dimethylpyridine, quinoline–sulfur compounds,...
03
Jun
The Conia-ene reaction refers to a class of intramolecular cyclization reactions between enols and alkenes or alkynes. In the late 1960s, the laboratory of Jean-Marie Conia began studying small carbocyclic molecules, particularly those formed via ene-type reactions involving carbonyl compounds. Based on this research, a comprehensive paper titled “The Thermal...
03
Jun
The Hosomi–Sakurai reaction, also known simply as the Sakurai reaction, is an allylation reaction in which allyltrimethylsilane reacts with an electrophile under the catalysis of a strong Lewis acid. This reaction was jointly developed by Professors Hideki Sakurai and Akio Hosomi, and it bears their names. It is one of...
03
Jun
The Alder ene reaction refers to a chemical reaction in which an alkene (ene) bearing an allylic hydrogen reacts with an enophile to form a new σ-bond, with a migration of the alkene double bond and a 1,5-hydrogen shift. The product is a substituted alkene in which the double bond...
03
Jun
The Nozaki–Hiyama–Kishi (NHK) reaction refers to the coupling reaction of allylic halides, alkenyl halides, or alkenyl triflates with aldehydes in the presence of nickel/chromium catalysts. In 1977, Tamejiro Hiyama and Hitoshi Nozaki discovered this reaction. They reported a chromium(II) salt solution prepared by reducing chromium chloride with lithium aluminum hydride,...
03
Jun
Friedländer synthesis reaction The Friedländer synthesis refers to the reaction between o-aminoaryl aldehydes or ketones and another molecule of an aldehyde or ketone to produce quinolines and their derivatives. This reaction was discovered by German chemist Paul Friedländer and is named after him. The Friedländer synthesis is a classical method...
