Polyethylene glycol (PEG) functional chain compounds are essential tools in the field of protein and material surface modification. These compounds serve as covalent macromolecular linkers, enhancing the functional properties of proteins and enabling precise surface engineering of solid materials.

Applications in Protein Surface Modification

PEG-functionalized chains offer several advantages in protein engineering:

• Improved water solubility of proteins
• Reduced immunogenicity of labeled biomolecules
• Enhanced in vivo stability, supporting therapeutic and diagnostic applications

Applications in Material Surface Functionalization

PEG spacers are widely used to functionalize surfaces such as:

• Quantum dots
• Self-assembled monolayers
• Nanoparticles

These modifications significantly reduce non-specific protein binding, allowing for more accurate and reliable experimental outcomes.

Breakthroughs by Researcher Li Xuebing

Li Xuebing, a researcher at the Institute of Microbiology, Chinese Academy of Sciences, has developed a series of advanced PEG functional chain products. One standout example is:

• Propynyl-triethylene glycol-amino (Product No.: 9110656)
  This compound, shown in Figure 1, links two single-chain antibody fragments (scFv), preventing the formation of dimers or trimers. This innovation enables the synthesis of bivalent scFv (di-scFv) with a high yield of up to 74%【1】.

J&K Scientific: Supporting Advanced Research

J&K Scientific proudly supplies PEG functional chain compounds developed by leading researchers like Li Xuebing. These products support cutting-edge research in:

• Protein modification
• Surface functionalization
• Biomedical and materials science applications

 

 Polyethylene glycol functionalized chains

9110656

932741-19-0

Propargyl-PEG3-amine, 95%

50mg

2096397

153870-20-3

S-Acetyl-PEG3-alcohol, 95%

50mg

9103733

932741-18-9

3-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)prop-1-yne, 95%

50mg

9110659

1598372-09-8

2-(2-(2-Azidoethoxy)ethoxy)ethyl 5-(1,2-dithiolan-3-yl)pentanoate, 95%

50mg

9110658

1441062-15-2

1-Azido-6-(prop-2-ynyloxy)hexane, 95%

100mg

9110657

1956300-51-8

2-(2-(2-(1,3-Diazidopropan-2-yloxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate, 95%

50mg

2323667

1163732-89-5

N-(2-(2-(2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, 95%

50mg

Functional small molecules

9110662

1321148-54-2

1-Azidosulfonyl-1H-imidazole hydrochloride, 95%

50mg

619008

38309-89-6

2,7-Bis(bromomethyl)naphthalene, 95%

250mg, 1g

9110661

31107-13-8

1,3-Diazido-2,2-bis(azidomethyl)propane, 95%

500mg

2034460

824426-32-6

2,5-Dioxopyrrolidin-1-yl 2-azidoacetate, 95%

300mg

654343

1155-51-7

4,4'-Dithiobisbenzoic acid, 95%

500mg

2490003

942060-16-4

(1-Tert-butyl-1H-1,2,3-triazol-4-yl)methanol, 95%

500mg

References

1. Arutselvan Natarajan, Wenjun Du, Cheng-Yi Xiong, Gerald L. DeNardo, Sally J. DeNardo, Jacquelyn Gervay-Hague. Chem. Commun. 2007, 7, 695-697.