Polyethylene glycol (PEG) functional chain compounds play a pivotal role in modifying the surface of proteins and materials. These compounds facilitate covalent macromolecular protein research by acting as linking arms while enhancing the functional properties of proteins.

Protein Surface Modification:

• Improves protein water solubility.
• Reduces the immunogenicity of labeled molecules.
• Enhances stability in vivo.

Surface Functionalization of Solid Materials:

• PEG spacers functionalize surfaces such as quantum dots, self-assembled monolayers, and nanoparticles.
• Significantly reduces non-specific protein binding, enabling more precise applications.

Researcher Li Xuebing from the Institute of Microbiology, Chinese Academy of Sciences, has developed a series of cutting-edge polyethylene glycol functional chain products.

One notable example is propynyl-triethylene glycol-amino (Product No.: 9110656). This compound, illustrated in Figure 1, connects two single-chain antibody fragments (scFv), effectively preventing them from forming dimers or trimers. By reducing undesired yields, it enables the synthesis of bivalent scFv (di-scFv) with an impressive yield of up to 74%【1】

 J&K Scientific proudly supplies polyethylene glycol functional chain compounds, facilitating advancements in protein modification and surface functionalization research.

 

 Polyethylene glycol functionalized chains

9110656

932741-19-0

Propargyl-PEG3-amine, 95%

50mg

2096397

153870-20-3

S-Acetyl-PEG3-alcohol, 95%

50mg

9103733

932741-18-9

3-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)prop-1-yne, 95%

50mg

9110659

1598372-09-8

2-(2-(2-Azidoethoxy)ethoxy)ethyl 5-(1,2-dithiolan-3-yl)pentanoate, 95%

50mg

9110658

1441062-15-2

1-Azido-6-(prop-2-ynyloxy)hexane, 95%

100mg

9110657

1956300-51-8

2-(2-(2-(1,3-Diazidopropan-2-yloxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate, 95%

50mg

2323667

1163732-89-5

N-(2-(2-(2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, 95%

50mg

Functional small molecules

9110662

1321148-54-2

1-Azidosulfonyl-1H-imidazole hydrochloride, 95%

50mg

619008

38309-89-6

2,7-Bis(bromomethyl)naphthalene, 95%

250mg, 1g

9110661

31107-13-8

1,3-Diazido-2,2-bis(azidomethyl)propane, 95%

500mg

2034460

824426-32-6

2,5-Dioxopyrrolidin-1-yl 2-azidoacetate, 95%

300mg

654343

1155-51-7

4,4'-Dithiobisbenzoic acid, 95%

500mg

2490003

942060-16-4

(1-Tert-butyl-1H-1,2,3-triazol-4-yl)methanol, 95%

500mg

References

1. Arutselvan Natarajan, Wenjun Du, Cheng-Yi Xiong, Gerald L. DeNardo, Sally J. DeNardo, Jacquelyn Gervay-Hague. Chem. Commun. 2007, 7, 695-697.