In August 2018, the team of Academician Shao Feng, deputy director of the Beijing Institute of Life Sciences, published a research paper titled "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose" in Nature, proving for the first time that two Adenosine heptose monophosphate (ADP-heptose) can be used as a true pathogen-associated pattern molecule (PAMP). It penetrates the mammalian cell membrane and is recognized by the new immune receptor kinase ALPK1 as a pattern recognition receptor (PRR), activating NF. Innate immune inflammatory response mediated by -κB pathway. [1][1][1]

Dr. Li Chao, senior researcher at Beijing Institute of Life Sciences, research directions: (1) Using new catalytic systems to study novel chemical bond construction methods to provide more ideal strategies for the synthesis of chemical molecules.
(2) Select natural products related to major diseases for synthesis and activity optimization, thereby promoting the research of innovative drugs;
(3) Explore the biological mechanism of active natural small molecules and their targets;
(4) Design and synthesize chemical tool molecules that can selectively label, track biological macromolecules or identify their interactions.

1. Zhou, P., et al. Nature. 2018, 561, 122-126.