Second region near-infrared (NIR-II) fluorescence imaging has been used widely in vivo due to its long excitation wavelength and the ability to achieve deep penetration depths, and high spatial resolution.

However, existing NIR-II fluorescent probes, such as single-walled carbon nanotubes (SWNTs), quantum dots, rare-earth nanoparticles, and other inorganic materials or polymer probes, have poor biocompatibility, in vivo metabolism, and safety, and cannot translate to clinical applications.

In 2015, Prof. Xuechuan Hong published an article in Nature Materials. For the first time, he successfully synthesized CH1055 (1000-1600 nm), a NIR-II fluorescent dye that can be metabolized by the kidney and label a variety of biomolecules^[1].

Advantages

• Metabolizable: the organism can be absorbed, metabolized and excreted through the kidney.
• Modifiable: modifiable sites can be added to connect bioactive substances and thus improve their water solubility and biocompatibility.
• Deeper penetration: Compared with NIR-I fluorescent dyes (700-1000 nm), CH1055 has a better ability to penetrate biological tissues (up to about 40μm), improving signal-to-noise ratio and spatial resolution.

CH1055 can be used for in vitro detection and in vivo imaging. It can also be used to detect cellular markers, tissue specimens, early diagnosis of disease, disease staging, intraoperative navigation therapy, and postoperative efficacy evaluation ^[2-10].

Reference:

1. Alexander L. Antaris, Xuechuan Hong. et al. Nat. Mater. 2016, 15(2), 235–242.
2. Alexander L. Antaris, Xuechuan Hong. et al. Nat. Commun. 2017, 8, 15269.
3. Shuqing He, Jun Song. Chem. Soc. Rev. 2018, 47, 4258-4278.
4. Bingbing Ding, Xuechuan Hong. et al. J. Med. Chem. 2019, 62, 2049−
5. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2018, 9, 2092–2097.
6. Jiacheng Lin, Xuechuan Hong. et al. Chem. Sci. 2019, 10, 1219-1126.
7. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2017, 8, 3489-3493.
8. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2016, 7，6203-6207.
9. Xiaodong Zeng, Xuechuan Hong. et al. Adv. Healthcare Mater. 2018, 7, 1800589.
10. Hui Zhou, Xuechuan Hong. et al. J. Mater. Chem. C 2019, 7, 9448-9454.

Dr. Hong’s Profile

Xuechuan Hong is a distinguished professor at Wuhan University. His research interests include the development of organic small-molecule probes in the second near-infrared region, tumor visualization, virus infection mechanisms and drug development. 

9146839 CH-1055, 95%

9146842 CH-1055-4T, 95%

9146843 CH-1055 NHS Ester, 95%

9146841 CH-1055-PEG-N3, 95%

9146840 CH-1055-PEG-Biotin, 95%