L-Aspartic Acid: Synthesis and Applications

L-Aspartic Acid finds widespread applications in medicine, food, and the chemical industry. In the field of medicine, it is employed for the treatment of heart diseases, liver disorders, hypertension, and possesses fatigue prevention and recovery properties. It is combined with various amino acids to formulate amino acid infusions, serving as a detoxifying agent, liver function enhancer, and fatigue recovery agent.


The synthesis of L-Aspartic Acid involves the addition of concentrated HCl (4 mL) to dissolve oxazaborolidinone (4 mmol) in methanol (8 mL). The reaction mixture is stirred at room temperature for 30 minutes, and the solvent is evaporated. Hot THF (20 mL) is added, and the mixture is stirred for an additional 15 minutes. The precipitate is collected by filtration, washed with hot THF (20 mL), and purified to obtain the desired compound, L-Aspartic Acid.

Synthesis Route of L-Aspartic Acid:

  1. Dissolve oxazaborolidinone (4 mmol) in methanol (8 mL) with the addition of concentrated HCl (4 mL).
  2. Stir the reaction mixture at room temperature for 30 minutes and evaporate the solvent.
  3. Add hot THF (20 mL) and stir the mixture for 15 minutes.
  4. Collect the precipitate by filtration, wash with hot THF (20 mL), and purify to obtain L-Aspartic Acid.

References: [1] Li Zhongfu, Bian Tao. Progress in the Production and Application of L-Aspartic Acid. Tianjin Chemical Industry, 2015, 29(01), 13-15.

[2] Terasaki, Masanori, et al. A New Pathway to Aspartic Acid from Urea and Maleic Acid Affected by Ultraviolet Light. Origins of Life and Evolution of the Biosphere, 2002, 32(2), 91-98.

By 向阳 翟


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