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Adding a keto group to an aromatic or aliphatic substrate using an acyl halide or anhydride in the presence of a Lewis acid catalyst is called the Friedel-Crafts acylation. The reactive electrophile in this aromatic substitution is either an acylium ion or an acyl chloride-Lewis acid complex.  Benzene and slightly deactivated derivatives tend to go through the acylium ion.  The aryl ketone can be converted to an alkyl chain via catalytic hydrogenation or the Clemmensen or Wolff-Kishner reduction.
- Reagents: Lewis Acid (AlX3, FeCl3, Lanthanide Triflates, etc.) or Protic Acid (H2SO4, H3PO4)
- Reactant: Aromatic, Acyl Halide or Anhydride
- Product: Aryl Ketone
- Type of Reaction: Electrophilic Substitution
- Electrophilic Aromatic Substitution
- Clemmensen Reduction
- Wolff-Kishner Reduction
- Aluminum Chloride (CAS 7446-70-0)
- Lewis Acid
- Acyl halide