Cope Rearrangement

The thermal [3,3][3,3]-sigmatropic shift, where bonds reorganize in a single, concerted step without forming intermediates.

Original Literature:

• Cope, A. C.; Hardy, E. M. The Introduction of Substituted Vinyl Groups. V. A Rearrangement Involving the Migration of an Allyl Group in a Three-Carbon System. J. Am. Chem. Soc. 1940, *62*(2), 441–444.

Popular Applications:

• The Hetero-Cope Rearrangement in Organic Synthesis. Synthesis 1989, *1989*(02), 71–82.

• Cope Rearrangement Revisited. J. Am. Chem. Soc. 1971, *93*(25), 6941–6948.

• *A Rapidly Reversible Degenerate Cope Rearrangement: Bicyclo[5.1.0]Octa-2,5-Diene.* Tetrahedron 1963, *19*(5), 715–737.