The Bischler–Napieralski Reaction refers to an intramolecular electrophilic substitution reaction in which β-aryl ethylamides undergo cyclization in the presence of chlorinating reagents to form 1,2-dihydroisoquinoline derivatives. This reaction was first discovered in 1893 by German chemist August Bischler and Swiss chemist Bernard Napieralski during their research on alkaloids. It is...

Bergman Cyclization is a reaction in which enediyne compounds undergo thermal or photochemical cyclization in the presence of a hydrogen donor (such as 1,4-cyclohexadiene) to form substituted benzene derivatives. The reaction is named after American chemist Robert G. Bergman. Due to the limited range of suitable substrates and stringent conditions,...

Blanc Chloromethylation refers to the reaction in which aromatic compounds react with formaldehyde and hydrogen chloride in the presence of anhydrous zinc chloride as a catalyst to form chloromethylated aromatic compounds. This reaction was first reported by Grassi-Cristaldi and Maselli in 1898 and later expanded by Blanc in 1923, hence...

Blaise Reaction refers to the reaction between a nitrile and an α-bromoester in the presence of zinc to form β-enamino esters or β-keto esters. It was first reported by Edmond Blaise in 1901 and is named after him. The Blaise reaction has certain drawbacks, such as a narrow substrate scope...

Bohlmann-Rahtz Pyridine Synthesis is an efficient two-step method for obtaining substituted pyridines. In the first step, an enamine condenses with an alkynone to form an aminodiene intermediate. This is followed by a thermally induced E/Z isomerization, and then a cyclodehydration reaction occurs, forming a 2,3,6-trisubstituted pyridine. The reaction was first...

Cadiot-Chodkiewicz Coupling Reaction The Cadiot-Chodkiewicz coupling refers to the catalytic coupling of a terminal alkyne with a haloalkyne in the presence of a copper(I) salt (e.g., cuprous chloride or cuprous bromide) and a base to yield a diyne derivative. This reaction was discovered by Paul Cadiot and W. Chodkiewicz and is named after them. The Cadiot-Chodkiewicz...