The Pinner Reaction refers to the acid-catalyzed reaction of nitriles with alcohols to form imidate salts (alkyl imidate hydrochlorides), known as Pinner salts, which can further react with water or ammonia to yield esters or amidines. This reaction was first discovered in 1877 by Adolf Pinner and is named after...

Newman–Kwart Rearrangement (NKR) refers to the thermal rearrangement of O-thiocarbamates to their corresponding S-thiocarbamates under high-temperature conditions. The reaction is named after its discoverers, Melvin Spencer Newman and Harold Kwart. The NKR is an important method for the synthesis of thiophenols and their derivatives. Reagents: Solvent (e.g., DMA, NMP) Reactant:...

The Finkelstein Reaction involves the substitution of a halogen atom in an alkyl halide with another halogen atom via an SN2 reaction, using acetone and a metal halide salt. The driving force behind the reaction is the lower solubility of the newly formed metal halide salt in acetone compared to...

Dess–Martin Oxidation refers to the oxidation of alcohols to the corresponding carbonyl compounds using Dess–Martin periodinane (DMP). The reaction is named after American chemists Daniel Benjamin Dess and James Cullen Martin. Dess–Martin periodinane (DMP), full name: 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, was developed in 1983 by the aforementioned chemists. The Dess–Martin oxidation can proceed...

Fukuyama Coupling refers to the reaction between organozinc compounds and thioesters under palladium catalysis to produce ketones. This reaction was discovered by Tohru Fukuyama and colleagues in 1998 and is named after him. Fukuyama Coupling has attracted widespread attention for its mild reaction conditions and high functional group compatibility, making...

The Fleming–Tamao oxidation is a reaction that converts silanes into alcohols using peracids or hydrogen peroxide. The reaction is named after Kohei Tamao and Ian Fleming, who independently reported slightly different versions of this transformation in 1983 and 1984, respectively. Reagents: Hydrogen peroxide or peracid, solvent, fluorinated additives Reactants: Silanes...