Fukuyama Coupling refers to the reaction between organozinc compounds and thioesters under palladium catalysis to produce ketones. This reaction was discovered by Tohru Fukuyama and colleagues in 1998 and is named after him. Fukuyama Coupling has attracted widespread attention for its mild reaction conditions and high functional group compatibility, making...

The Fleming–Tamao oxidation is a reaction that converts silanes into alcohols using peracids or hydrogen peroxide. The reaction is named after Kohei Tamao and Ian Fleming, who independently reported slightly different versions of this transformation in 1983 and 1984, respectively. Reagents: Hydrogen peroxide or peracid, solvent, fluorinated additives Reactants: Silanes...

Acid chlorides can be selectively reduced to their corresponding aldehydes using hydrogen gas in the presence of a partially deactivated palladium catalyst, known as the Rosenmund catalyst. This catalyst is prepared by depositing palladium (Pd) on barium sulfate (BaSO₄) and then poisoning it with additives such as 2,6-dimethylpyridine, quinoline–sulfur compounds,...

The Conia-ene reaction refers to a class of intramolecular cyclization reactions between enols and alkenes or alkynes. In the late 1960s, the laboratory of Jean-Marie Conia began studying small carbocyclic molecules, particularly those formed via ene-type reactions involving carbonyl compounds. Based on this research, a comprehensive paper titled “The Thermal...

The Hosomi–Sakurai reaction, also known simply as the Sakurai reaction, is an allylation reaction in which allyltrimethylsilane reacts with an electrophile under the catalysis of a strong Lewis acid. This reaction was jointly developed by Professors Hideki Sakurai and Akio Hosomi, and it bears their names. It is one of...

The Alder ene reaction refers to a chemical reaction in which an alkene (ene) bearing an allylic hydrogen reacts with an enophile to form a new σ-bond, with a migration of the alkene double bond and a 1,5-hydrogen shift. The product is a substituted alkene in which the double bond...