Cope Rearrangement The thermal [3,3]-sigmatropic isomerization of 1,5-dienes is known as the Cope rearrangement. This reaction was discovered by Arthur C. Cope and Elizabeth Hardy and is named after them. This reaction belongs to the class of sigmatropic rearrangements, where a σ bond adjacent to at least one π bond migrates while the π system...
27
May
Cope Elimination Reaction The Cope elimination refers to the reaction in which a tertiary amine is oxidized to an "N-oxide" intermediate, followed by thermal decomposition to yield an alkene and an N,N-disubstituted hydroxylamine. This reaction is named after the American chemist Arthur C. Cope. The Cope elimination plays a significant role in organic...
27
May
Corey-Fuchs Reaction The Corey-Fuchs reaction refers to the transformation of an aldehyde into a terminal alkyne through a two-step process: first, the aldehyde reacts with carbon tetrabromide (CBr₄) and triphenylphosphine (PPh₃) to form a dibromoolefin, which is then treated with n-butyllithium (n-BuLi) to yield the terminal alkyne. This reaction is named after the American chemists E. J. Corey and Philip L....
27
May
Corey–Seebach Reactive The Corey–Seebach reaction, also known as the Seebach Umpolung reaction, is a classic reaction that achieves nucleophilic acylation of carbonyl carbon atoms through a "polarity reversal" (Umpolung) strategy. In this reaction, an aldehyde (or ketone) first reacts with 1,3-propanedithiol to form a 1,3-dithiane intermediate, which is then lithiated...
26
May
The Corey-Winter olefin synthesis is a series of chemical reactions that convert 1,2-diols into alkenes. The process begins with the reaction of a diol with thiophosgene to form a cyclic thiocarbonate. This intermediate then undergoes deoxygenation in the presence of trimethyl phosphite, yielding the corresponding alkene. The reaction is named after the...
26
May
Darzens condensation reaction equation The Darzens condensation, also known as the Darzens reaction or glycidic ester condensation, is a process in which a ketone or aldehyde reacts with an α-halo ester in the presence of a base to yield an α,β-epoxy ester (comm referred to as a "glycidic ester")....
