Blanc Chloromethylation refers to the reaction in which aromatic compounds react with formaldehyde and hydrogen chloride in the presence of anhydrous zinc chloride as a catalyst to form chloromethylated aromatic compounds. This reaction was first reported by Grassi-Cristaldi and Maselli in 1898 and later expanded by Blanc in 1923, hence...
27
May
Blaise Reaction refers to the reaction between a nitrile and an α-bromoester in the presence of zinc to form β-enamino esters or β-keto esters. It was first reported by Edmond Blaise in 1901 and is named after him. The Blaise reaction has certain drawbacks, such as a narrow substrate scope...
27
May
Bohlmann-Rahtz Pyridine Synthesis is an efficient two-step method for obtaining substituted pyridines. In the first step, an enamine condenses with an alkynone to form an aminodiene intermediate. This is followed by a thermally induced E/Z isomerization, and then a cyclodehydration reaction occurs, forming a 2,3,6-trisubstituted pyridine. The reaction was first...
27
May
Cadiot-Chodkiewicz Coupling Reaction The Cadiot-Chodkiewicz coupling refers to the catalytic coupling of a terminal alkyne with a haloalkyne in the presence of a copper(I) salt (e.g., cuprous chloride or cuprous bromide) and a base to yield a diyne derivative. This reaction was discovered by Paul Cadiot and W. Chodkiewicz and is named after them. The Cadiot-Chodkiewicz...
27
May
Cope Rearrangement The thermal [3,3]-sigmatropic isomerization of 1,5-dienes is known as the Cope rearrangement. This reaction was discovered by Arthur C. Cope and Elizabeth Hardy and is named after them. This reaction belongs to the class of sigmatropic rearrangements, where a σ bond adjacent to at least one π bond migrates while the π system...
27
May
Cope Elimination Reaction The Cope elimination refers to the reaction in which a tertiary amine is oxidized to an "N-oxide" intermediate, followed by thermal decomposition to yield an alkene and an N,N-disubstituted hydroxylamine. This reaction is named after the American chemist Arthur C. Cope. The Cope elimination plays a significant role in organic...
