The Nozaki–Hiyama–Kishi (NHK) reaction refers to the coupling reaction of allylic halides, alkenyl halides, or alkenyl triflates with aldehydes in the presence of nickel/chromium catalysts. In 1977, Tamejiro Hiyama and Hitoshi Nozaki discovered this reaction. They reported a chromium(II) salt solution prepared by reducing chromium chloride with lithium aluminum hydride,...
03
Jun
Friedländer synthesis reaction The Friedländer synthesis refers to the reaction between o-aminoaryl aldehydes or ketones and another molecule of an aldehyde or ketone to produce quinolines and their derivatives. This reaction was discovered by German chemist Paul Friedländer and is named after him. The Friedländer synthesis is a classical method...
27
May
The Baker–Venkataraman rearrangement refers to the transformation of ortho-acyloxyaryl ketones into the corresponding aryl β-diketones via a rearrangement reaction. It is named after chemists W. Baker and Krishnaswamy Venkataraman. The Baker–Venkataraman rearrangement is one of the most widely used methods for synthesizing chromones, flavones, and isoflavones. Reagents: BaseReactants: Ortho-acyloxyaryl ketonesProducts:...
27
May
The Schiemann reaction, also known as the Balz–Schiemann reaction, is a transformation in which an aromatic primary amine is converted into an aryl fluoride via a diazonium tetrafluoroborate intermediate under heating or photolytic conditions. The reaction was discovered in 1927 by German chemists Günther Schiemann and Günther Balz, and is...
27
May
The Bamford–Stevens reaction refers to the base-catalyzed decomposition of tosylhydrazones derived from aldehydes or ketones to generate alkenes. This reaction was first reported in 1952 by British chemist William Randall Bamford and Scottish chemist Thomas Stevens Stevens, and is named after them. When carried out in aprotic solvents, the reaction...
27
May
The Barton–McCombie Reaction is an organic reaction in which a hydroxyl functional group in an organic compound is replaced by a hydrogen atom, forming an alkane. This reaction was discovered in 1975 by British chemists Derek Harold Richard Barton and Stuart W. McCombie, and is named after them. It is...
