Triptycene is a molecule with a unique three-dimensional rigid structure composed of three benzene rings (Figure 1). The angles between the three benzene rings are all 120°, forming three open electron-rich cavities. Because its structure resembles a medieval triptych, it is called triptylene. In recent years, its unique structural characteristics...

4,4’-Dibenzoic acid is one of the important monomers for the synthesis of general-purpose high-performance polymers and liquid crystal materials. However, this monomer has shortcomings such as long industrial synthesis route, heavy pollution, low selectivity, and poor biodegradability of the synthesized polymer. Under increasingly severe environmental control and carbon neutrality restrictions,...

4,4’-Dibenzoic acid is one of the important monomers for the synthesis of general-purpose high-performance polymers and liquid crystal materials [1]. However, this monomer has shortcomings such as long industrial synthesis route, heavy pollution, low selectivity, and poor biodegradability of the synthesized polymer. Under increasingly severe environmental control and carbon neutrality...

The disulfide skeleton containing two covalently linked sulfur atoms is an important molecular structure in life sciences, medical sciences, and food chemistry due to its unique pharmacological and physicochemical properties (Figure 1). For example, disulfide bonds in biomolecules play various roles in various biochemical redox processes; the secondary and tertiary...

Fluorine is an important non-metal element. Due to its unique electronegativity, electronic effect and steric hindrance effect, fluorine atoms are often introduced into drugs to regulate drug metabolism pathways, improve metabolic stability and permeability, etc., and have been More than 20% of drugs and pesticides on the market contain one...

Trifluoromethylthio group is one of the most lipophilic groups. Introducing it into small molecule compounds can significantly enhance the ability of molecules to penetrate lipid membranes and increase the absorption rate in the body (Figure 1). Therefore, incorporating trifluoromethyl sulfide (CF3S) into drug candidates has become an important strategy for...