Heterocalixarene and crown arene are two new types of synthetic macrocyclic main molecules. Heterocalixarene has a finely adjustable 1,3-alternating conformation structure and V-shaped macrocyclic cavity [1], and crown arene has a cylindrical shape. Heterocalixarenes and crownarenes composed of cavities, different heteroatoms, aromatic rings and aromatic heterocycles exhibit rich and unique...

Sugar nucleotides are formed by connecting the reducing end of a monosaccharide to the terminal phosphate group of a nucleoside diphosphate (or nucleoside monophosphate), and are the activated form of a monosaccharide. It can serve as a donor substrate for glycosyltransferases and participate in the enzymatic synthesis of complex oligosaccharides...

Hyaluronan (HA) and chondroitin (CH) are two important glycosaminoglycans that are widely present on the cell surface and extracellular matrix. They can interact with cytokines, cell adhesion molecules, selectins, and enzymes to regulate intracellular signaling pathways [1]. At the same time, it is also widely used in medicine, cosmetics and...

Asymmetric catalysis is one of the most active branches in modern organic chemistry research, and asymmetric catalytic reactions are considered to be the most efficient methods for synthesizing chiral substances. The principle is to convert achiral raw materials into chiral products by using chiral catalysts. Therefore, the chiral ligand complexed...

Chemical cross-linking coupled with mass spectrometry (CXMS) has been booming in the past decade and is widely used in protein structure identification and protein interaction analysis. However, the chemical cross-linking agents available for CXMS technology are limited and the cross-linking efficiency is not high enough, which limits the application of...

Chemotherapy is currently the main means of treating cancer, but tumor cells may develop drug resistance, and the mechanism is complex. High levels of reduced glutathione (GSH) may be an important reason for this phenomenon. To reveal the detailed role of GSH in chemoresistance, it is crucial to find a...