Hyaluronan (HA) and chondroitin (CH) are two important glycosaminoglycans that are widely present on the cell surface and extracellular matrix. They can interact with cytokines, cell adhesion molecules, selectins, and enzymes to regulate intracellular signaling pathways [1]. At the same time, it is also widely used in medicine, cosmetics and...

Asymmetric catalysis is one of the most active branches in modern organic chemistry research, and asymmetric catalytic reactions are considered to be the most efficient methods for synthesizing chiral substances. The principle is to convert achiral raw materials into chiral products by using chiral catalysts. Therefore, the chiral ligand complexed...

Chemical cross-linking coupled with mass spectrometry (CXMS) has been booming in the past decade and is widely used in protein structure identification and protein interaction analysis. However, the chemical cross-linking agents available for CXMS technology are limited and the cross-linking efficiency is not high enough, which limits the application of...

Chemotherapy is currently the main means of treating cancer, but tumor cells may develop drug resistance, and the mechanism is complex. High levels of reduced glutathione (GSH) may be an important reason for this phenomenon. To reveal the detailed role of GSH in chemoresistance, it is crucial to find a...

Introduction: The Critical Role of Peroxynitrite (ONOO⁻) in Disease Pathology Peroxynitrite anion (ONOO-) plays a key regulatory role in many physiological processes and is closely related to the occurrence of oxidative damage, ischemic stroke, neurodegenerative diseases, cancer and other diseases.As a highly reactive nitrogen species, ONOO⁻ is implicated in nitrosative...

Changes in intracellular and intracellular pH play an important role in physiological and pathological processes. Changes in intracellular pH can easily induce cell division, rapid growth and functional disorders. The reduction of extracellular pH to acidic is an important signal for cancer and other lesions. Therefore, the detection of pH...