Amphotericin B from?Streptomyces?species|38472|1397-89-3

Amphotericin B from?Streptomyces?species

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Sku CI38472_250_MG
Chem Impex
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Product Information

Product Name
Amphotericin B from?Streptomyces?species
Brand Name
Chem Impex
Product Number
38472
CAS
1397-89-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
5280965
IUPAC Name
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yloxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo33.3.1nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
InChI Key
APKFDSVGJQXUKY-INPOYWNPSA-N
SMILES
CC@H1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C@@H(CC@H2C@@H(C@H(CC@(O2)(CC@H(CC@H(C@@H(CCC@H(CC@H(CC(=O)OC@H(C@@H(C@@H1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC@H3C@H(C@H(C@@H(C@H(O3)C)O)N)O

Application

Amphotericin B from Streptomyces species is widely utilized in research focused on:

Antifungal Treatments: This compound is a cornerstone in treating serious fungal infections, particularly in immunocompromised patients, such as those undergoing chemotherapy or with HIV/AIDS.

Pharmaceutical Development: Researchers are continually exploring formulations that enhance the efficacy and reduce the toxicity of Amphotericin B, leading to innovative drug delivery systems.

Veterinary Medicine: It is also used in veterinary practices to treat fungal infections in animals, showcasing its versatility across species.

Research on Drug Resistance: Scientists study Amphotericin B to understand mechanisms of antifungal resistance, which is crucial for developing new therapeutic strategies.

Combination Therapies: This compound is often used in combination with other antifungal agents to improve treatment outcomes and minimize side effects, making it a valuable tool in clinical settings.

References

Correction: Multiomics analysis revealed the regulatory role of Chenodeoxycholic acid in fatty acid metabolism and lipid homeostasis
Publication Name: Lipids in Health and Disease
Publication Date: 2025-10-14
DOI: 10.1186/s12944-025-02656-w|10.1186/s12944-025-02752-x

Pulmonary fungal infection caused by Rhizopus microsporus in type II diabetic patient:A case report
Publication Name: Diagnostic Microbiology and Infectious Disease
Publication Date: 2025-10
DOI: 10.1016/j.diagmicrobio.2025.116953

Correction: Successful treatment of meglumine antimoniate in patient with cutaneous leishmaniasis with end-stage renal failure undergoing hemodialysis: a case report
Publication Name: Journal of Medical Case Reports
Publication Date: 2025-09-19
DOI: 10.1186/s13256-025-05331-x|10.1186/s13256-025-05490-x

A convenient and rapid LC-MS/MS method for determination of free and liposomal amphotericin B in human plasma by simultaneous separation using SPE
Publication Name: Journal of Pharmaceutical and Biomedical Analysis
Publication Date: 2025-09-01
DOI: 10.1016/j.jpba.2025.116884

Correction: Current trends on antifungal prophylaxis in solid organ transplantation: a study from ESCMID-EFISG, ESCMID-ESGICH, SITA, and SEIMC-GESITRA-IC
Publication Name: Infection
Publication Date: 2025-09-01
DOI: 10.1007/s15010-025-02575-z|10.1007/s15010-025-02625-6