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Chem Impex
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Product Information

Product Name
Amphotericin B
Brand Name
Chem Impex
Product Number
00329
CAS
1397-89-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
5280965
IUPAC Name
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yloxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo33.3.1nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
InChI Key
APKFDSVGJQXUKY-INPOYWNPSA-N
SMILES
CC@H1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C@@H(CC@H2C@@H(C@H(CC@(O2)(CC@H(CC@H(C@@H(CCC@H(CC@H(CC(=O)OC@H(C@@H(C@@H1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC@H3C@H(C@H(C@@H(C@H(O3)C)O)N)O

Application

Amphotericin B is widely utilized in research focused on

Antifungal Treatment: It is primarily used to treat serious fungal infections, especially in immunocompromised patients, providing a critical option where other treatments may fail.

Pharmaceutical Development: Researchers use it as a benchmark compound in the development of new antifungal agents, allowing for comparative studies on efficacy and safety.

Drug Formulation: Its unique properties are leveraged in the formulation of liposomal drugs, enhancing the delivery and reducing toxicity, which is vital for patient compliance.

Veterinary Medicine: Amphotericin B is also applied in veterinary practices to treat fungal infections in animals, ensuring broader applications in healthcare.

Research on Drug Resistance: It serves as a key compound in studies investigating antifungal resistance mechanisms, helping to inform future therapeutic strategies.

References

Silver Nanoparticles Prepared Using Magnolia officinalis Are an Effective Antimicrobial Agent on Candida albicans, Escherichia coli, and Staphylococcus aureus

Publication Name: Probiotics and Antimicrobial Proteins
Publication Date: 2025-04
DOI: 10.1007/s12602-023-10179-y

Correction: Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery

Publication Name: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Publication Date: 2025-02-26
DOI: 10.1007/s40199-024-00546-7|10.1007/s40199-025-00555-0

Candida auris MIC testing by EUCAST and clinical and laboratory standards institute broth microdilution, and gradient diffusion strips; to be or not to be amphotericin B resistant?

Publication Name: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Publication Date: 2025-01
DOI: 10.1016/j.cmi.2024.10.010

Trabecular Meshwork Regeneration for Glaucoma Treatment Using Stem Cell-Derived Trophic Factors

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4087-6_4

Controlled Release of Molecules to Enhance Cell Survival and Regeneration

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4087-6_16