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Chem Impex
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Product Information

Product Name
Fmoc-D-leucine
Brand Name
Chem Impex
Product Number
02427
CAS
114360-54-2
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
1549477
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
InChI Key
CBPJQFCAFFNICX-LJQANCHMSA-N
SMILES
CC(C)CC@H(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Application

Fmoc-D-leucine is widely utilized in research focused on:

Peptide Synthesis: This compound is a key building block in the synthesis of peptides, allowing researchers to create specific sequences for therapeutic applications.

Drug Development: Its role in drug design is crucial, particularly in developing peptide-based drugs that target specific biological pathways, enhancing efficacy and reducing side effects.

Biotechnology: In the field of biotechnology, Fmoc-D-leucine is employed in the production of recombinant proteins, aiding in the development of vaccines and enzymes.

Research in Neuroscience: This compound is used in studies exploring neurotransmitter interactions, contributing to advancements in understanding neurological disorders.

Custom Synthesis Services: Many laboratories offer custom synthesis of Fmoc-D-leucine derivatives, providing tailored solutions for specific research needs and enhancing experimental flexibility.

References

Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants

Publication Name: Nature Biomedical Engineering
Publication Date: 2025-05-29
DOI: 10.1038/s41551-025-01404-w

Diol as a New Pantetheine Surrogate for Chemoenzymatic Synthesis of Cyclic Peptides via Nonribosomal Peptide Cyclases

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4562-8_10

Accurate de novo design of heterochiral protein–protein interactions

Publication Name: Cell Research
Publication Date: 2024-08-14
DOI: 10.1038/s41422-024-01014-2

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Publication Name: iScience
Publication Date: 2024-02-16
DOI: 10.1016/j.isci.2024.108907

Design, synthesis and antibacterial activity of novel colistin derivatives with thioether bond-mediated cyclic scaffold

Publication Name: The Journal of Antibiotics
Publication Date: 2023-03-20
DOI: 10.1038/s41429-023-00606-1