(D-Arg1,D-Trp7·9,Leu11)-Substance P

Name: (D-Arg1,D-Trp7·9,Leu11)-Substance P | 91224-37-2
Brand: US-CATO
SKU: S57CPTD787481_10_MG
Price: 19998.0 USD
Availability: OutOfStock

Cat. No S57CPTD787481_10_MG

Vendor: US-CATO

Product Information

Product Name

(D-Arg1,D-Trp7·9,Leu11)-Substance P

Brand Name

US-CATO

Product Number

CPTD787481

CAS

91224-37-2

Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

44458789

IUPAC Name

(2S)-2-(2S)-2-(2S)-2-(2S)-2-(2S)-2-(2S)-4-amino-2-(2S)-2-(2R)-1-(2S)-2-(2S)-1-(2S)-6-amino-2-(pyridine-3-carbonylamino)hexanoyl-3-pyridin-3-ylpyrrolidine-2-carbonylaminopropanoyl-3,4-dichloropyrrolidine-2-carbonylamino-3-phenylpropanoylamino-4-oxobutanoylamino-3-(1H-indol-3-yl)propanoylamino-3-phenylpropanoylamino-3-(1H-indol-3-yl)propanoylamino-4-methylpentanoylaminohexanoic acid

InChI Key

GFMHGFPPCYBUCK-HBUFSDLISA-N

SMILES

CCCCC@@H(C(=O)O)NC(=O)C@H(CC(C)C)NC(=O)C@H(CC1=CNC2=CC=CC=C21)NC(=O)C@H(CC3=CC=CC=C3)NC(=O)C@H(CC4=CNC5=CC=CC=C54)NC(=O)C@H(CC(=O)N)NC(=O)C@H(CC6=CC=CC=C6)NC(=O)C@@H7C(C(CN7C(=O)C@H(C)NC(=O)C@@H8C(CCN8C(=O)C@H(CCCCN)NC(=O)C9=CN=CC=C9)C1=CN=CC=C1)Cl)Cl

References Data Source From Pubchem

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

Publication Name: The Journal of biological chemistry

Publication Date: 2021-01

DOI: 10.1016/j.jbc.2021.100345

UVR-B-induced NKR-1 Expression in Ocular Tissues is blocked by Substance P Receptor Antagonist Fosaprepitant in the Exposed as well as Unexposed Partner Eye

Publication Name: Ocular Immunology and Inflammation

Publication Date: 2020-02-14

DOI: 10.1080/09273948.2019.1708414

Behavioral sensitization induced by dorsal periaqueductal gray electrical stimulation is counteracted by NK1 receptor antagonism in the ventral hippocampus and central nucleus of the amygdala

Publication Name: Neurobiology of Learning and Memory

Publication Date: 2018-02

DOI: 10.1016/j.nlm.2018.01.009

Inhibition of substance P-induced defensive behavior via neurokinin-1 receptor antagonism in the central and medial but not basolateral nuclei of the amygdala in male Wistar rats

Publication Name: Progress in Neuro-Psychopharmacology and Biological Psychiatry

Publication Date: 2017-07-03

DOI: 10.1016/j.pnpbp.2017.03.026

Dorsal periaqueductal gray post-stimulation freezing is counteracted by neurokinin-1 receptor antagonism in the central nucleus of the amygdala in rats

Publication Name: Neurobiology of Learning and Memory

Publication Date: 2015-05

DOI: 10.1016/j.nlm.2015.04.001