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Sku CI30045_5_G
Chem Impex
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Product Information

Product Name
6-Chloroguanosine
Brand Name
Chem Impex
Product Number
30045
CAS
2004-07-1
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
102197
IUPAC Name
(2R,3R,4S,5R)-2-(2-amino-6-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
InChI Key
TXWHPSZYRUHEGT-UUOKFMHZSA-N
SMILES
C1=NC2=C(N1C@H3C@@H(C@@H(C@H(O3)CO)O)O)N=C(N=C2Cl)N

Application

6-Chloroguanosine is widely utilized in research focused on:

Antiviral Research: This compound is studied for its potential to inhibit viral replication, making it a candidate for developing antiviral therapies.

RNA Studies: It serves as a building block in RNA synthesis, allowing researchers to explore RNA structure and function, which is crucial for understanding genetic processes.

Pharmaceutical Development: The compound is being investigated for its therapeutic properties, particularly in the treatment of various diseases, including cancer and viral infections.

Biochemical Assays: 6-Chloroguanosine is used in assays to measure enzyme activity, helping researchers understand metabolic pathways and enzyme functions.

Drug Design: Its unique chemical properties make it a valuable tool in the design of new drugs, particularly those targeting nucleic acids.

References Data Source From Pubchem

Practical synthesis of N-(di-n-butylamino)methylene-protected 2-aminopurine riboside phosphoramidite for RNA solid-phase synthesis

Publication Name: Monatshefte für Chemie - Chemical Monthly
Publication Date: 2019-10-11
DOI: 10.1007/s00706-019-02502-7

Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases

Publication Name: Journal of Medicinal Chemistry
Publication Date: 2017-10-03
DOI: 10.1021/acs.jmedchem.7b01066

Testing Nucleoside Analogues as Inhibitors of Bacillus anthracis Spore Germination In Vitro and in Macrophage Cell Culture

Publication Name: Antimicrobial Agents and Chemotherapy
Publication Date: 2010-12
DOI: 10.1128/aac.01029-10

Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

Publication Name: Bioorganic & Medicinal Chemistry Letters
Publication Date: 2007-05-01
DOI: 10.1016/j.bmcl.2007.02.026