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Chem Impex
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Product Information

Product Name
2',3'-O-Isopropylideneguanosine
Brand Name
Chem Impex
Product Number
30047
CAS
362-76-5
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
135445744
IUPAC Name
9-(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro3,4-d1,3dioxol-4-yl-2-amino-1H-purin-6-one
InChI Key
XKPDAYWPKILAMO-IOSLPCCCSA-N
SMILES
CC1(OC@@H2C@H(OC@H(C@@H2O1)N3C=NC4=C3N=C(NC4=O)N)CO)C

Application

2',3'-O-Isopropylideneguanosine is widely utilized in research focused on:

Nucleotide Synthesis: This compound serves as a key intermediate in the synthesis of modified nucleotides, which are essential for developing new nucleic acid-based therapies and diagnostics.

Pharmaceutical Development: It plays a significant role in the pharmaceutical industry, particularly in the formulation of antiviral and anticancer drugs, enhancing their efficacy and stability.

Biochemical Research: Researchers use it to study enzyme interactions and nucleic acid behavior, providing insights into genetic regulation and potential therapeutic targets.

Drug Delivery Systems: Its unique properties allow for the design of advanced drug delivery systems that improve the bioavailability of therapeutic agents, making treatments more effective.

Diagnostic Applications: This compound is also utilized in the development of diagnostic tools, particularly in assays that detect viral infections, thereby aiding in timely medical interventions.

References

An NMR crystallography study of the hemihydrate of 2′, 3′-O-isopropylidineguanosine

Publication Name: Solid State Nuclear Magnetic Resonance
Publication Date: 2015-02
DOI: 10.1016/j.ssnmr.2015.01.001

G-quadruplex self-assembly regulated by Coulombic interactions

Publication Name: Nature Chemistry
Publication Date: 2009-04-19
DOI: 10.1038/nchem.177

Catalytic Condensation of Phosphoric Acid with Alcohols

Publication Name: Science of Synthesis
Publication Date: 2009

Synthesis and application of a new 2′,3′-isopropylidene guanosine substituted cap analog

Publication Name: Bioorganic & Medicinal Chemistry Letters
Publication Date: 2008-09-01
DOI: 10.1016/j.bmcl.2008.07.075

Supramolecular Polymers Based on the Quadruplex Formation of Ditopic Guanosine Macromonomers in Nonaqueous Media

Publication Name: Langmuir : the ACS journal of surfaces and colloids
Publication Date: 2007-04-03
DOI: 10.1021/la070019g