Superoxide anion (O2•−), as the primary precursor of reactive oxygen species (ROS), is closely associated with ferroptosis-mediated epilepsy. Therefore, establishing an efficient and convenient method for real-time dynamic monitoring of superoxide anion (O2•−) during ferroptosis in epilepsy is of great importance for the diagnosis and treatment of ferroptosis-mediated epilepsy. However, no probe for detecting superoxide anion (O2•−) in ferroptosis-mediated epilepsy has been reported to date.
Professor Tang Zhixin from Shandong University of Traditional Chinese Medicine has developed a novel near-infrared fluorescent probe—NIR-FP—capable of precisely tracking superoxide anion fluctuations. In an epilepsy model, this probe was used for the first time to detect and visualize the dynamic changes in superoxide anion concentration during ferroptosis-mediated epilepsy.
Product Advantages
-
NIR-FP exhibits high selectivity and sensitivity toward O2•− in physiological environments (Figure 2);
-
NIR-FP possesses broad biocompatibility (Figure 3);
-
NIR-FP enables real-time monitoring of superoxide anion fluctuations (Figure 4)
| Tang Zhixin is a Lecturer and Master's Supervisor at Shandong University of Traditional Chinese Medicine, holding a Ph.D. from Dalian University of Technology (2020). His research focuses on developing fluorescent probes for disease biomarkers and their applications in bioimaging, as well as utilizing fluorescence-based methods for screening active components in traditional Chinese medicine. He has led research projects funded by the Shandong Natural Science Foundation and the China Postdoctoral Science Foundation. His achievements include receiving the 2024 Science and Technology Award from the China National Association of Ethnic Medicine and a Silver Prize in the National Postdoctoral Innovation Competition. He has published 13 papers as first or corresponding author in journals such as Biosensors and Bioelectronics, Sensors and Actuators B: Chemical, and Analytical Chemistry. | 
|
Related Product:
- #Cat:9423829 NIR-FP, 90%
Notice for Bulk/Industrial Orders
To ensure you receive the most accurate pricing and terms for your specific needs, all purchases require a custom quote.
Please contact our sales team to discuss your requirements and receive a formal quotation.
We appreciate your interest and look forward to supporting your large-scale projects.
艳 李
