In 2016, Professor Xuechuan Hong at Wuhan University published a paper in Nature Materials [1], reporting the first successful synthesis of a metabolizable near-infrared II (NIR-II) small-molecule dye—CH1055—capable of labeling various biomolecules.

With a maximum emission wavelength in the range of 1000–1600 nm, CH1055 exhibits excellent biocompatibility, clearance properties, and imaging sensitivity. It can serve as a NIR-II reporter molecule for both in vitro detection and in vivo imaging (Figure 1), and is suitable for applications such as detecting cellular markers, tissue specimens, early disease diagnosis, disease staging, intraoperative navigation, and post-treatment efficacy evaluation [2–10].

Bio-Ling (J&K Scientific) exclusively offers the NIR-II small-molecule fluorescent dye CH1055 and its derivatives developed by Professor Hong's research group:

• Modifiable: Featuring additional modification sites for conjugating bioactive substances, thereby improving water solubility and biocompatibility;

• Metabolizable: Can be absorbed and metabolized by the body, with clearance via the kidneys;

• Enhanced biocompatibility and safety: Compared to traditional NIR-II fluorescent materials such as single-walled carbon nanotubes (SWNTs) and quantum dots, CH1055 offers superior biocompatibility, in vivo metabolism, and safety;

• Superior imaging performance: Compared to NIR-I (700–1000 nm) fluorescent dyes, CH1055 provides deeper tissue penetration (up to approximately 40 μm), as well as higher imaging signal-to-noise ratio and resolution.

Related Products

• CH-1055, 95% Cas:1622250-38-7 Cat:9146839
  
• CH-1055-PEG-Biotin, 95%  Cat:9146840
• CH-1055-PEG-N3, 95%  Cat:9146841
• CH-1055-4T, 95%  Cat:9146842
• CH-1055 NHS Ester, 95%  Cat:9146843

References

1. Alexander L. Antaris, Xuechuan Hong. et al. Nat. Mater. 2016, 15(2), 235–242.
2. Alexander L. Antaris, Xuechuan Hong. et al. Nat. Commun. 2017, 8, 15269.
3. Shuqing He, Jun Song. Chem. Soc. Rev. 2018, 47, 4258-4278.
4. Bingbing Ding, Xuechuan Hong. et al. J. Med. Chem. 2019, 62, 2049−2059.
5. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2018, 9, 2092–2097.
6. Jiacheng Lin, Xuechuan Hong. et al. Chem. Sci. 2019, 10, 1219-1126.
7. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2017, 8, 3489-3493.
8. Yao Sun, Xuechuan Hong. et al. Chem. Sci. 2016, 7，6203-6207.
9. Xiaodong Zeng, Xuechuan Hong. et al. Adv. Healthcare Mater. 2018, 7, 1800589.
10. Hui Zhou, Xuechuan Hong. et al. J. Mater. Chem. C 2019, 7, 9448-9454.