CH-1055-PEG-N3, 95%

General Description

In 2016, Professor Hong Xuechuan from Wuhan University published an article in Nature Materials, reporting the first successful synthesis of a near-infrared window II (NIR-II) small-molecule dye—CH1055—that can label various biomolecules and be metabolized by organisms.
Its maximum emission wavelength ranges from 1000 nm to 1600 nm. CH1055 is non-toxic, absorbable, and possesses good biocompatibility and imaging sensitivity. It can serve as a NIR-II reporter molecule for in vitro detection and in vivo imaging, as well as for detecting cellular markers, tissue specimens, early disease diagnosis, disease staging, intraoperative navigation, and postoperative efficacy evaluation.

Product Advantages

• Provides additional modifiable sites for conjugating bioactive substances, thereby improving water solubility and biocompatibility.
• Absorbable by the body and excreted via the kidneys.
• Compared with traditional NIR-II fluorescent dyes such as single-walled carbon nanotubes (SWNTs) and quantum dots (inorganic materials), CH1055 offers better biocompatibility, in vivo metabolism, and in vivo safety.
• With a maximum emission wavelength between 1000 nm and 1600 nm, CH1055 exhibits deeper tissue penetration (up to ~40 μm) than NIR-I (700–1000 nm) fluorescent dyes.
• Higher imaging signal-to-noise ratio and resolution.

Applications

CH1055 can be used as a NIR-II reporter molecule for in vitro detection and in vivo imaging, as well as for detecting cellular markers, tissue specimens, early disease diagnosis, disease staging, intraoperative navigation, and postoperative efficacy evaluation. Specific examples include:

• An innovative probe, CH1055-GRRRDEVDK (CH1055-GK), was synthesized using CH1055 to specifically bind caspase-3, enabling imaging of skin avulsion injuries and defining necrotic areas [1].
• CH1055-F3 demonstrated high spatial and temporal resolution, strong tumor uptake, and remarkable NIR-II image-guided surgery specificity in DMBA-induced spontaneous breast tumor rats [2].
• Two homologous fluorescent probes, CH1055-PEG-PT and CH1055-PEG-BODY, showed promising results for targeted imaging of osteosarcoma and its lung metastases, respectively. The study found that NIR-II imaging quality of CH1055-PEG-PT far exceeded that of CT [3].
• The cartilage-targeting probe CH1055-WL enabled visual monitoring of articular cartilage (AC) degeneration in living subjects [4].
• The small-molecule NIR-II fluorophore CH1055 conjugated with FSH (FSH-CH) was used for imaging of ovaries and testes in live mice [5].
• The NIR-II probe CH1055-MCM2 was evaluated in mice bearing HepG2 xenografts, achieving favorable imaging properties such as good tumor uptake, high tumor contrast, and specificity. This strategy may identify new targets for liver cancer imaging and therapy [6].
• The uPAR-targeting probe CH1055-4Glu-AE105 enabled imaging of orthotopic glioblastoma (GBM) through an intact skull [7].

References

• 1、Li, Yizhou; Hu, Xiang; Yi, Wanrong; Li, Daifeng; Guo, Yaqi; Qi, Baiwen; Yu, Aixi，Frontiers in Chemistry (Lausanne, Switzerland) (2019), 7, 696.
• 2、Zhou, Hui; Li, Shanshan; Zeng, Xiaodong; Hong, Xuechuan; et al. Chinese Chemical Letters (2020), 31(6), 1382-1386.
• 3、Zhou, Hui; Yi, Wanrong. Li, Anguo. Wang, Tian. et al. Advanced Healthcare Materials (2020), 9(1), 1901224.
• 4、Yi, Wanrong. Zhou, Hui. Li, Anguo. et al. Biomaterials Science (2019), 7(3), 1043-1051.
• 5、Feng, Yi. Zhu, Shoujun. Antaris, Alexander L.. Chen, Hao. et al. Chemical Science (2017), 8(5), 3703-3711
• 6、Yang, Jing. Xie, Qi. Zhou, Hui. Chang, Lei. et al. Journal of Proteome Research (2018), 17(7), 2428-2439.
• 7、Kurbegovic, Sorel; Juhl, Karina; Chen, Hao. et al. Bioconjugate Chemistry (2018), 29(11), 3833-3840.