Asymmetric catalysis is one of the research hotspots in the field of organic synthesis. According to the type of catalyst, it can be divided into metal complex catalysis, organic small molecule catalysis and enzyme catalysis. Chiral ligands are crucial for metal complex catalysts, but most ligands have narrow application ranges, limiting their applications.
Feng Xiaoming's research group at Sichuan University has been committed to research on asymmetric catalysis for the past 20 years, designed flexible chiral nitrogen-oxygen ligands, and carried out systematic and in-depth research work. Currently, this type of ligand can form complexes with more than 20 metal ions (including main group metals, transition metals and rare earth metals), catalyze more than 50 types of asymmetric reactions, and provides a simple and efficient new way to synthesize chiral molecules. Professor Noyori, Nobel Prize winner in Chemistry, commented that it “represents a class of dominant chiral ligands”.
Figure 1 Representative asymmetric reactions involving Feng's chiral dinitroxide ligand-metal complex[1]
Its advantages are as follows：
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Broad Applicability: It can be used as an organocatalyst or as a ligand to form complex catalysts with various metals, demonstrating excellent stereoselectivity in both cases.
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Tunable Structure: Combining both rigidity and flexibility, it allows for substituent modifications according to the requirements of the reaction.
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Good Solubility and High Stability: Soluble in both polar and non-polar solvents, insensitive to air and moisture, and reactive at room temperature.
Feng's Chiral Nitroxide Ligand Series Products
Feng's Ligand with Piperidine Backbone：
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| Product Name | NO-Feng-PDiPPPi, L-PiPr2, 99% |
NO-Feng-PTMPPP, L-PiMe3, 99% |
| Cas | 1000051-40-0 | 1310585-10-4 |
| Cat.No | 1595285 | 1595286 |
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| Product Name | NO-Feng-PDEtPPi, L-PiEt2, 95% |
NO-Feng-PBuPPi, L-PitBu, 95% |
| Cas | 1313215-46-1 | 959152-93-3 |
| Cat.No | 2699018 | 2699022 |
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| Product Name | NO-Feng-PPhPPi, L-PiPh, 95% |
NO-Feng-PBnPPi, L-PiBn, 95% |
| Cas | 945564-77-2 | 1085279-20-4 |
| Cat.No | 2699020 | 2699021 |
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| Product Name | NO-Feng-PDEtMPPi, L-PiEt2Me, 95% | NO-Feng-PCyPPi, L-PicH, 95% |
| Cas | 1502814-74-5 | 1017605-60-5 |
| Cat.No | 2699019 | 2699023 |
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| Product Name | NO-Feng-PDMPPi, L-PiMe2, 95% | |
| Cas | 1227411-35-9 | |
| Cat.No | 2699017 |
Product List of Feng's Ligands with Proline Backbone：
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| Product Name | NO-Feng-PBnPPr, L-PrBn, 95% | NO-Feng-PDEtMPPr, L-PrEt2Me, 95% |
| Cas | 870716-86-2 |
1502814-73-4 |
| Cat.No | 2699014 | 2699015 |
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| Product Name | NO-Feng-PDEtPPr, L-PrEt2, 95% | NO-Feng-PDiPPPr, L-PrPr2, 99% |
| Cas | 1313215-45-0 |
945564-85-2 |
| Cat.No | 2699012 | 1595283 |
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| Product Name | NO-Feng-PDMPPy, L-PrMe2, 99% | NO-Feng-PDPhMPPr, L-PrCPh2, 95% |
| Cas |
1330533-36-2 |
870716-88-4 |
| Cat.No | 1595284 | 2699016 |
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| Product Name | NO-Feng-PPhPPr, L-PrPh, 95% | |
| Cas |
945564-81-8 |
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| Cat.No | 2699013 |
Product List of Feng's Ligands with Ramipril Backbone：
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| Product Name | NO-Feng-PDiPPRa, L-RaPr2, 95% | NO-Feng-PDMPRa, L-RaMe2, 99% |
| Cas |
1005495-74-8 |
1132049-44-5 |
| Cat.No | 1595287 | 1595288 |
Related Product
Metal salt：
| Product Name | CAS | Cat.No |
|---|---|---|
| Copper(II) trifluoromethanesulfonate, 98% |
34946-82-2 | 208060 |
| Iron(II) trifluoromethanesulfonate, 98% (Iron triflate) |
59163-91-6 | 26-2830 |
| Lanthanum trifluoromethanesulfonate, 98% |
52093-26-2 | 526606 |
| Magnesium trifluoromethanesulfonate, 98% |
60871-83-2 | 152796 |
| Nickel(II) trifluoromethanesulfonate, 96% |
60871-84-3 | 810702 |
| Samarium(III) trifluoromethanesulfonate, 98% |
52093-28-4 | 246805 |
| Scandium(III) triflate, 98% |
144026-79-9 | 302513 |
| Ytterbium(III) trifluoromethanesulfonate, 98% |
54761-04-5 | 904954 |
Chiral Oxazoline Ligand：
| Product Name | CAS | Cat.No |
|---|---|---|
| 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine, 98% |
128249-70-7 | 299174 |
| 2,6-Bis[(4R)-(+)-isopropyl-2-oxazolin-2-yl]pyridine, 98% |
131864-67-0 | 353382 |
| 2,6-Bis[(4S)-(-)-isopropyl-2-oxazolin-2-yl]pyridine, 99% |
118949-61-4 | 358083 |
| 4-Bromo-2,6-bis[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]-pyridine, 95% |
1190936-03-8 | 1710789 |
Solvent：
| Product Name | CAS | Cas.No |
|---|---|---|
| 1,2-Dichloroethane, 99% |
107-06-2 | 353972 |
| 1,1,2,2-Tetrachloroethane, 98.5% |
79-34-5 | 470939 |
| Acetonitrile, 99.9%, SuperDry, water≤10 ppm, J&KSeal |
75-05-8 | 980779 |
| Benzotrifluoride, 99%, SuperDry, water≤10 ppm, J&KSeal |
98-08-8 | 350291 |
| Chlorobenzene, 99% |
108-90-7 | 292651 |
| Dichloromethane, 99.9%, SuperDry, with molecular sieves, water≤30 ppm, J&KSeal |
75-09-2 | 908525 |
| Ethyl acetate, 99.5%, SuperDry, J&KSeal |
141-78-6 | 954403 |
| Tetrahydrofuran, 99.5%, SuperDry, with molecular sieves, stabilized with 250 ppm BHT, J&KSeal |
109-99-9 | 974643 |
| tert-Butanol, 99.5%, ACS reagent |
75-65-0 | 926353 |
