(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate|CS-0376818|2252403-85-1

(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate

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Product Information

Product Name
(3S)-tert-Butyl 4-(6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-2-oxo-1,2-dihydropyrido2,3-dpyrimidin-4-yl)-3-methylpiperazine-1-carboxylate
Brand Name
ChemScene
Product Number
CS-0376818
CAS
2252403-85-1
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
137278743
IUPAC Name
tert-butyl (3S)-4-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-yl-3-pyridinyl)-2-oxopyrido2,3-dpyrimidin-4-yl-3-methylpiperazine-1-carboxylate
InChI Key
PETFFVPRVBVQKQ-IBGZPJMESA-N
SMILES
CC@H1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)OC(C)(C)C

References

Synthesis of Sotorasib
Publication Name: Synfacts
Publication Date: 2021-09-17
DOI: 10.1055/s-0040-1720181

Sotorasib
Publication Name: Pharmaceutical Substances
Publication Date: 2021

Synthesis of AMG 510
Publication Name: Synfacts
Publication Date: 2020-02-18
DOI: 10.1055/s-0039-1691693

A First-in-Class, Clinically-Relevant Covalent Inhibitor of KRAS(G12C)
Publication Name: Synfacts
Publication Date: 2020-01-21
DOI: 10.1055/s-0039-1691636