Hexafluoroisopropanol, 99+%

Product Introduction

Hexafluoroisopropanol (CAS No. 920-66-1), commonly abbreviated as HFIP, is a highly fluorinated alcohol with strong hydrogen-bond donating ability, high polarity, and low nucleophilicity. Its molecular formula is C₃H₂F₆O and molecular weight is 168.04 g/mol.

The two electron-withdrawing trifluoromethyl groups give Hexafluoroisopropanol distinctive solvent and solvation properties, making it valuable for organic synthesis, peptide chemistry, analytical chemistry, chromatography, spectroscopy, polymer research, and materials science.

Hexafluoroisopropanol is available in different purity and application grades, including grades for HPLC, LC-MS, peptide synthesis, spectroscopy, and general research.

Mechanism / Principle

Highly Fluorinated Solvent Properties

The two –CF₃ groups strongly withdraw electron density from the central carbon bearing the hydroxyl group. This gives Hexafluoroisopropanol a combination of:

• Strong hydrogen-bond donating ability
• High polarity
• Low nucleophilicity
• Strong solvation of suitable polar compounds
• Ability to influence molecular conformation and reaction pathways

These properties make HFIP particularly useful when conventional organic solvents cannot provide the required solvation or reaction environment.

Key Research Applications

1. HPLC and LC-MS

Hexafluoroisopropanol is used as a specialty solvent and mobile-phase component in analytical workflows.

Applications include:

• HPLC
• LC-MS
• Mass spectrometry
• Peptide analysis
• Biomolecule analysis
• Specialty chromatographic methods

2. Peptide Chemistry

HFIP is widely used in peptide-related research because of its ability to interact strongly with peptide structures.

Applications include:

• Peptide synthesis
• Peptide solubilization
• Peptide conformational studies
• Peptide aggregation research
• Biomolecular chemistry

3. Organic Synthesis

Hexafluoroisopropanol can function as a specialty reaction solvent and reaction medium.

Applications include:

• Organic synthesis
• Reaction optimization
• Catalytic reactions
• Functional-group transformations
• Mechanistic studies

4. Polymer and Materials Research

HFIP can dissolve or process selected polymers that have limited solubility in conventional solvents.

Applications include:

• Polymer dissolution
• Polymer processing
• Polymer characterization
• Electrospinning
• Functional polymer research
• Biomaterial preparation

5. Spectroscopy

High-purity Hexafluoroisopropanol can be used in analytical and spectroscopic research.

Applications include:

• NMR spectroscopy
• Infrared spectroscopy
• Molecular structure studies
• Solution-state characterization
• Reaction monitoring

6. Analytical Sample Preparation

HFIP is also used in specialized analytical workflows, including sample preparation and derivatization.

Applications include:

• GC derivatization
• Analytical sample preparation
• Chromatographic analysis
• Mass spectrometry
• Chemical analysis

Advantages

• Highly fluorinated specialty solvent
• Strong hydrogen-bond donating capability
• High polarity
• Low nucleophilicity
• Useful for polar and fluorinated compounds
• Suitable for peptide research
• Applicable to HPLC and LC-MS
• Suitable for organic synthesis
• Useful in polymer and materials research
• Available in multiple purity and application grades

Storage & Handling

• Store in a tightly closed container.
• Keep in a cool, dry and well-ventilated location.
• Protect from heat and ignition sources.
• Avoid unnecessary exposure to moisture and contamination.
• Handle in a suitable fume hood.
• Avoid contact with skin and eyes.
• Avoid inhalation of vapors.
• Wear appropriate gloves, protective clothing, and eye protection.
• Use compatible containers and laboratory equipment.
• Follow the product-specific SDS for storage, handling and disposal.

Research Areas

Researchers working in the following fields may benefit from Hexafluoroisopropanol (CAS No. 920-66-1):

• Organic synthesis
• Analytical chemistry
• HPLC
• LC-MS
• Mass spectrometry
• Peptide chemistry
• Biochemistry
• Polymer chemistry
• Materials science
• Spectroscopy

Q1: What is Hexafluoroisopropanol?

A: Hexafluoroisopropanol is a highly fluorinated alcohol with CAS No. 920-66-1, molecular formula C₃H₂F₆O, and molecular weight 168.04 g/mol.

Q2: What is the abbreviation for Hexafluoroisopropanol?

A: The commonly used abbreviation is HFIP.

Q3: What is Hexafluoroisopropanol used for?

A: Hexafluoroisopropanol is mainly used as a specialty solvent for HPLC, LC-MS, peptide chemistry, organic synthesis, spectroscopy, polymer research, and analytical chemistry.

Q4: What is the molecular weight of Hexafluoroisopropanol?

A: The molecular weight is 168.04 g/mol.

Q5: Is Hexafluoroisopropanol used in HPLC?

A: Yes. HFIP is available in dedicated HPLC grades and is used as a specialty solvent or mobile-phase component in chromatographic methods.

Q6: Is Hexafluoroisopropanol used in LC-MS?

A: Yes. High-purity LC-MS grades of Hexafluoroisopropanol are used in mass-spectrometric and chromatographic workflows.

Q7: Is Hexafluoroisopropanol used in peptide research?

A: Yes. HFIP is widely used in peptide-related research, including peptide solubilization, synthesis workflows, and conformational studies.

Q8: Is Hexafluoroisopropanol the same compound as 1,1,1,3,3,3-Hexafluoropropan-2-ol?

A: Yes. Hexafluoroisopropanol is the commonly used name for 1,1,1,3,3,3-Hexafluoropropan-2-ol, CAS 920-66-1.