Ketoconazole|37983|65277-42-1

Ketoconazole

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Sku CI37983_25_G
Chem Impex
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Product Information

Product Name
Ketoconazole
Brand Name
Chem Impex
Product Number
37983
CAS
65277-42-1
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
47576
IUPAC Name
1-4-4-(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenylpiperazin-1-ylethanone
InChI Key
XMAYWYJOQHXEEK-ZEQKJWHPSA-N
SMILES
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC@@H3COC@@(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Application

Ketoconazole is widely utilized in research focused on:

Antifungal Treatments: Commonly used in dermatology, ketoconazole is effective against various fungal infections, such as athlete's foot and ringworm, providing relief and promoting skin health.

Shampoos for Scalp Conditions: Incorporated into medicated shampoos, it helps treat dandruff and seborrheic dermatitis by reducing fungal growth on the scalp, improving overall hair and scalp condition.

Hormonal Imbalance Management: In endocrinology, ketoconazole is used to manage conditions like Cushing's syndrome by inhibiting cortisol production, assisting patients in regulating hormone levels.

Research in Drug Development: As a model compound, it aids in the study of antifungal mechanisms and resistance, helping researchers develop more effective antifungal agents.

Veterinary Medicine: Utilized in treating fungal infections in animals, ketoconazole supports veterinary professionals in managing pet health, particularly for skin and systemic fungal issues.

References Data Source From Pubchem

In vitro disruption of the retinoic acid signaling pathway by industrial chemicals and pharmaceuticals
Publication Name: Toxicology and Applied Pharmacology
Publication Date: 2025-12
DOI: 10.1016/j.taap.2025.117577

DNA binding study of antifungal drug Ketoconazole by molecular docking and spectroscopic analysis
Publication Name: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Publication Date: 2025-11-15
DOI: 10.1016/j.saa.2025.126351

Metabolic activation and cytotoxicity of bavachin mediated by CYP3A in mice
Publication Name: Chemico-Biological Interactions
Publication Date: 2025-10-08
DOI: 10.1016/j.cbi.2025.111630

Quantitative analysis of endocrine disruption by ketoconazole and diethylstilbestrol in rat mammary gland development
Publication Name: Reproductive toxicology (Elmsford, N.Y.)
Publication Date: 2025-08
DOI: 10.1016/j.reprotox.2025.108929

Thermal analysis and FTIR in supplier qualification: Evidence of impurities and risks associated with handling
Publication Name: Journal of Pharmaceutical Sciences
Publication Date: 2025-08
DOI: 10.1016/j.xphs.2025.103880