2'-Deoxy-L-thymidine|28646|3424-98-4

2'-Deoxy-L-thymidine

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Sku CI28646_1_G
Chem Impex
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Product Information

Product Name
2'-Deoxy-L-thymidine
Brand Name
Chem Impex
Product Number
28646
CAS
3424-98-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
159269
IUPAC Name
1-(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl-5-methylpyrimidine-2,4-dione
InChI Key
IQFYYKKMVGJFEH-CSMHCCOUSA-N
SMILES
CC1=CN(C(=O)NC1=O)C@@H2CC@H(C@@H(O2)CO)O

Application

2'-Deoxy-L-thymidine is widely utilized in research focused on:

DNA Synthesis: This compound is a crucial building block for synthesizing DNA in molecular biology, enabling researchers to create specific DNA sequences for various applications, including gene cloning and synthetic biology.

Antiviral Research: It plays a significant role in developing antiviral therapies, particularly against viral infections like HIV. Its incorporation into antiviral drugs can help inhibit viral replication.

Cancer Research: Researchers use this compound in studies related to cancer cell proliferation and apoptosis, providing insights into potential therapeutic strategies for cancer treatment.

Biotechnology: In the biotech industry, it is used in the production of recombinant proteins, where DNA constructs are essential for expressing proteins in host cells.

Diagnostic Tools: 2'-Deoxy-L-thymidine is employed in the development of diagnostic assays, including PCR (Polymerase Chain Reaction) techniques, which are vital for detecting genetic material in various samples.

References

Real-world clinical data-driven modelling on the initiation time of antiviral prophylaxis among pregnant women with chronic hepatitis B infection
Publication Name: Journal of Hepatology
Publication Date: 2025-05
DOI: 10.1016/j.jhep.2024.11.017

DFT/TDDFT calculations of geometry optimization, electronic structure and spectral properties of clevudine and telbivudine for treatment of chronic hepatitis B
Publication Name: Scientific Reports
Publication Date: 2024-04-08
DOI: 10.1038/s41598-024-58599-2

Creatine kinase elevation in chronic hepatitis B patients with telbivudine therapy: influence of telbivudine plasma concentration and single nucleotide polymorphisms of TK2, RRM2B, and NME4
Publication Name: European Journal of Clinical Pharmacology
Publication Date: 2024-03-19
DOI: 10.1007/s00228-024-03674-w

Comparison of the efficacy and safety of TAF, TDF, and LdT to prevent the transmission of hepatitis B in pregnant women: A retrospective study
Publication Name: Immunity, Inflammation and Disease
Publication Date: 2024-02
DOI: 10.1002/iid3.1204

The molecular feature of abnormal fetal neuromuscular development after maternal use of telbivudine or tenofovir during pregnancy in rodent model
Publication Name: Life Sciences
Publication Date: 2023-12-01
DOI: 10.1016/j.lfs.2023.122177