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Sku CI21207_1_G
Chem Impex
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Product Information

Product Name
4-Fluoro-DL-tryptophan
Brand Name
Chem Impex
Product Number
21207
CAS
25631-05-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
101198
IUPAC Name
2-amino-3-(4-fluoro-1H-indol-3-yl)propanoic acid
InChI Key
DEBQMEYEKKWIKC-UHFFFAOYSA-N
SMILES
C1=CC2=C(C(=C1)F)C(=CN2)CC(C(=O)O)N

Description

4-Fluoro-DL-tryptophan is widely utilized in research focused on:

Pharmaceutical Development: This compound serves as a valuable building block in the synthesis of novel pharmaceuticals, particularly in the development of drugs targeting neurological disorders.

Biochemical Research: It is used in studies investigating the role of tryptophan derivatives in protein synthesis and metabolism, helping researchers understand fundamental biological processes.

Neuroscience Applications: The compound is explored for its potential effects on serotonin pathways, making it a candidate for research into mood disorders and depression treatments.

Protein Engineering: 4-Fluoro-DL-tryptophan can be incorporated into proteins to study the impact of fluorinated amino acids on protein structure and function, providing insights into enzyme activity.

Analytical Chemistry: It is utilized as a standard in mass spectrometry and chromatography, aiding in the accurate analysis of complex biological samples.

References Data Source From Pubchem

Additive CHARMM36 Force Field for Nonstandard Amino Acids

Publication Name: Journal of Chemical Theory and Computation
Publication Date: 2021-05-19
DOI: 10.1021/acs.jctc.1c00254

Highlight: Changing the Canon--Revisiting a Classic Experiment to Alter the Genetic Code

Publication Name: Genome Biology and Evolution
Publication Date: 2014-03-26
DOI: 10.1093/gbe/evu053

Mutations Enabling Displacement of Tryptophan by 4-Fluorotryptophan as a Canonical Amino Acid of the Genetic Code

Publication Name: Genome Biology and Evolution
Publication Date: 2014-02-25
DOI: 10.1093/gbe/evu044

Residue-Specific Incorporation of Unnatural Amino Acids into Proteins In Vitro and In Vivo

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2013
DOI: 10.1007/978-1-62703-293-3_7

Mechanistic Studies on CymD: A Tryptophan Reverse N-Prenyltransferase

Publication Name: Biochemistry
Publication Date: 2012-09-19
DOI: 10.1021/bi3009054