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Chem Impex
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Product Information

Product Name
(2S,4S)-Fmoc-4-fluoro-pyrrolidine-2-carboxylic acid
Brand Name
Chem Impex
Product Number
14494
CAS
203866-19-7
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2756199
IUPAC Name
(2S,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
InChI Key
CJEQUGHYFSTTQT-SGTLLEGYSA-N
SMILES
C1C@@H(CN(C@@H1C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)F

Application

(2S,4S)-Fmoc-4-fluoro-pyrrolidine-2-carboxylic acid is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a valuable building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, enhancing the efficiency and yield of the process.

Drug Development: Its unique structure allows for the design of novel pharmaceutical compounds, particularly in the development of drugs targeting neurological disorders, where fluorinated compounds can improve bioavailability.

Bioconjugation: The chemical is used in bioconjugation applications, facilitating the attachment of biomolecules to surfaces or other molecules, which is crucial in creating targeted drug delivery systems.

Research in Organic Chemistry: It plays a significant role in organic synthesis, allowing chemists to explore new reaction pathways and develop innovative synthetic methodologies.

Analytical Chemistry: This compound can be utilized in analytical techniques, such as chromatography, to improve the separation and identification of complex mixtures, enhancing the accuracy of analytical results.

References

Impacts of terminal (4R)-fluoroproline and (4S)-fluoroproline residues on polyproline conformation

Publication Name: Amino Acids
Publication Date: 2014-06-20
DOI: 10.1007/s00726-014-1783-2

Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)

Publication Name: International Journal of Peptide Research and Therapeutics
Publication Date: 2012-07-08
DOI: 10.1007/s10989-012-9313-0