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Sku CI12006_25_G
Chem Impex
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Product Information

Product Name
S-4-Methoxyltrityl-L-cysteine
Brand Name
Chem Impex
Product Number
12006
CAS
177582-20-6
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
7472794
IUPAC Name
(2R)-2-amino-3-(4-methoxyphenyl)-diphenylmethylsulfanylpropanoic acid
InChI Key
QAINHNNAIDVCEZ-NRFANRHFSA-N
SMILES
COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCC@@H(C(=O)O)N

Description

S-4-Methoxyltrityl-L-cysteine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for the selective modification of amino acids without interfering with other functional groups.

Drug Development: It plays a crucial role in the design of new pharmaceuticals, particularly in the development of cysteine-containing drugs, enhancing their stability and bioavailability.

Bioconjugation: The compound is used in bioconjugation techniques, where it helps in attaching biomolecules to surfaces or other molecules, which is essential in creating targeted drug delivery systems.

Research in Cancer Therapy: Its application in cancer research is notable, as it aids in the development of targeted therapies that can selectively attack cancer cells, minimizing damage to healthy tissues.

Diagnostics: S-4-Methoxyltrityl-L-cysteine is also utilized in diagnostic applications, particularly in the creation of biosensors that detect specific biomolecules, improving the accuracy of medical tests.

References Data Source From Pubchem

Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors

Publication Name: ACS Omega
Publication Date: 2018-09-28
DOI: 10.1021/acsomega.8b00778

Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors

Publication Name: ACS Medicinal Chemistry Letters
Publication Date: 2015-07-28
DOI: 10.1021/acsmedchemlett.5b00221

Optimized S-Trityl-l-cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models

Publication Name: Journal of Medicinal Chemistry
Publication Date: 2013-02-27
DOI: 10.1021/jm3014597

Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity

Publication Name: Journal of Medicinal Chemistry
Publication Date: 2012-02-13
DOI: 10.1021/jm201195m

Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity

Publication Name: Bioorganic & Medicinal Chemistry
Publication Date: 2011-09-15
DOI: 10.1016/j.bmc.2011.07.054