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Sku CI05596_25_G
Chem Impex
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Product Information

Product Name
Boc-L-pyroglutamic acid
Brand Name
Chem Impex
Product Number
05596
CAS
53100-44-0
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
104412
IUPAC Name
(2S)-1-(2-methylpropan-2-yl)oxycarbonyl-5-oxopyrrolidine-2-carboxylic acid
InChI Key
MJLQPFJGZTYCMH-LURJTMIESA-N
SMILES
CC(C)(C)OC(=O)N1C@@H(CCC1=O)C(=O)O

Description

Boc-L-pyroglutamic acid is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids without affecting others. This is crucial in developing complex peptides for pharmaceuticals.

Drug Development: Its role in medicinal chemistry is significant, particularly in designing compounds that target specific biological pathways. Researchers leverage its structural properties to enhance the efficacy and selectivity of drug candidates.

Bioconjugation: Boc-L-pyroglutamic acid is used in bioconjugation processes, where it helps attach biomolecules to drugs or imaging agents, improving their delivery and effectiveness in targeted therapies.

Protein Engineering: In the field of protein engineering, this compound aids in modifying proteins to improve their stability and activity, which is essential for developing better therapeutic proteins.

Research in Neurobiology: Its derivatives are explored in neurobiology for their potential effects on neurotransmitter systems, providing insights into neurological disorders and paving the way for new treatment strategies.

References Data Source From Pubchem

Synthesis of β-Lactamase Inhibitor Relebactam

Publication Name: Synfacts
Publication Date: 2020-02-18
DOI: 10.1055/s-0039-1691698

Pyroglutamyl leucine, a peptide in fermented foods, attenuates dysbiosis by increasing host antimicrobial peptide

Publication Name: npj Science of Food
Publication Date: 2019-10-07
DOI: 10.1038/s41538-019-0050-z

Formal Synthesis of (–)-Oseltamivir Phosphate

Publication Name: Synthesis
Publication Date: 2012-12-20
DOI: 10.1055/s-0032-1317948

Synthetic approaches to peptides containing the l-Gln-l-Val-D(S)-Dmt motif

Publication Name: Bioorganic & Medicinal Chemistry
Publication Date: 2007-05-15
DOI: 10.1016/j.bmc.2007.03.005