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Sku CI05138_5_G
Chem Impex
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Product Information

Product Name
Fmoc-L-propargylglycine
Brand Name
Chem Impex
Product Number
05138
CAS
198561-07-8
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2734461
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)pent-4-ynoic acid
InChI Key
DJGMNCKHNMRKFM-SFHVURJKSA-N
SMILES
C#CCC@@H(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Description

Fmoc-L-propargylglycine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a building block in the synthesis of peptides, particularly in the creation of modified peptides that can enhance biological activity or stability.

Drug Development: It plays a crucial role in the development of novel therapeutics, especially in the design of inhibitors that target specific enzymes or receptors in various diseases.

Bioconjugation: The alkyne group in Fmoc-L-propargylglycine allows for click chemistry applications, enabling researchers to attach biomolecules to surfaces or other molecules efficiently.

Research in Neuroscience: This compound is used in studies related to neuropeptides, aiding in the understanding of neurological pathways and potential treatments for neurodegenerative diseases.

Material Science: It is also explored in the development of smart materials that respond to environmental stimuli, showcasing its versatility beyond traditional applications.

References Data Source From Pubchem

β-Hairpin Peptidomimetics for Protein-Protein Interaction Inhibition

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4578-9_4

Different Approaches to Cyclize a Cell-Penetrating Peptide and to Tether Bioactive Payloads

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2022
DOI: 10.1007/978-1-0716-1689-5_20

Helical Stabilization of Peptide MacrocyclesPeptidemacrocycles by Stapled Architectures

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2022
DOI: 10.1007/978-1-0716-1689-5_21

On-DNA-1,2,3-Triazole Formation via Click Reaction

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2022
DOI: 10.1007/978-1-0716-2545-3_6

Enhanced antimicrobial activity of silver nanoparticles conjugated with synthetic peptide by click chemistry

Publication Name: Journal of Nanoparticle Research
Publication Date: 2020-04-15
DOI: 10.1007/s11051-020-04799-6