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Sku CI04038_100_G
Chem Impex
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Product Information

Product Name
Na-Boc-Nim-trityl-L-histidine
Brand Name
Chem Impex
Product Number
04038
CAS
32926-43-5
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
13968084
IUPAC Name
(2S)-2-(2-methylpropan-2-yl)oxycarbonylamino-3-(1-tritylimidazol-4-yl)propanoic acid
InChI Key
OYXZPXVCRAAKCM-SANMLTNESA-N
SMILES
CC(C)(C)OC(=O)NC@@H(CC1=CN(C=N1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)O

Description

Na-Boc-Nim-trityl-L-histidine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a protecting group in the synthesis of peptides, allowing for selective reactions without unwanted side reactions. Its stability under various conditions makes it a preferred choice for researchers.

Drug Development: It plays a crucial role in the development of pharmaceutical compounds, particularly in designing histidine-containing drugs that can target specific biological pathways effectively.

Bioconjugation: The compound is used in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, enhancing the functionality of drugs and diagnostic agents.

Research in Enzyme Activity: Researchers utilize it to study enzyme mechanisms and interactions, particularly those involving histidine residues, providing insights into enzyme function and regulation.

Protein Engineering: It aids in the modification of proteins to improve their stability and activity, which is essential in various biotechnological applications, including the development of biosensors and therapeutic proteins.

References Data Source From Pubchem

Serine/Threonine Ligation and Cysteine/Penicillamine Ligation

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2022-06-28
DOI: 10.1007/978-1-0716-2489-0_3

Drug Delivery Through Multifunctional Polypeptidic HydrogelsHydrogels

Publication Name: Supramolecules in Drug Discovery and Drug Delivery
Publication Date: 2021
DOI: 10.1007/978-1-0716-0920-0_10

QSPR modeling of optical rotation of amino acids using specific quantum chemical descriptors

Publication Name: Journal of Molecular Modeling
Publication Date: 2018-02-17
DOI: 10.1007/s00894-018-3593-z

Screening of efficient siRNA carriers in a library of surface-engineered dendrimers

Publication Name: Scientific Reports
Publication Date: 2016-04-28
DOI: 10.1038/srep25069

The racemization of histidine in peptide synthesis: Further studies

Publication Name: Peptides 1994
Publication Date: 1995
DOI: 10.1007/978-94-011-1468-4_77