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Sku CI03711_1_G
Chem Impex
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Product Information

Product Name
Na-Fmoc-Nim-methyltrityl-L-histidine
Brand Name
Chem Impex
Product Number
03711
CAS
133367-34-7
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
15138103
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-1-(4-methylphenyl)-diphenylmethylimidazol-4-ylpropanoic acid
InChI Key
MNOCIIYDYLYWEU-LHEWISCISA-N
SMILES
CC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)CC@@H(C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57

Description

Na-Fmoc-Nim-methyltrityl-L-histidine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, allowing for the creation of complex and functional peptides that are essential in drug development.

Drug Development: Its ability to protect functional groups during chemical reactions makes it valuable in pharmaceutical research, where precise modifications of amino acids are necessary for developing new therapeutic agents.

Bioconjugation: The compound is used in bioconjugation processes, enabling the attachment of peptides to other biomolecules, which is crucial for creating targeted drug delivery systems in cancer therapy.

Research in Protein Engineering: Researchers utilize this chemical to modify histidine residues in proteins, enhancing their stability and activity, which is significant in enzyme engineering and biocatalysis.

Diagnostic Applications: Its role in the synthesis of peptide-based probes aids in the development of diagnostic tools, improving the detection of diseases through targeted imaging techniques.

References Data Source From Pubchem

Synthesis of orthogonally protected azahistidine: application to the synthesis of a GHK analogue

Publication Name: Amino Acids
Publication Date: 2009-02-15
DOI: 10.1007/s00726-009-0248-5

A new synthesis of the tripeptide Gly-His-Lys with antimicrobial activity

Publication Name: Amino Acids
Publication Date: 1997-06
DOI: 10.1007/bf01373213

Solid phase synthesis using trityl type side chain protecting groups

Publication Name: Peptides 1992
Publication Date: 1993
DOI: 10.1007/978-94-011-1470-7_117