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Product Information

Product Name
Boc-L-phenylalanine N-hydroxysuccinimide ester
Brand Name
Chem Impex
Product Number
03674
CAS
3674-06-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
107447
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) (2S)-2-(2-methylpropan-2-yl)oxycarbonylamino-3-phenylpropanoate
InChI Key
NHUCANAMPJGMQL-ZDUSSCGKSA-N
SMILES
CC(C)(C)OC(=O)NC@@H(CC1=CC=CC=C1)C(=O)ON2C(=O)CCC2=O

Application

Boc-L-phenylalanine N-hydroxysuccinimide ester is widely utilized in research focused on:

Peptide Synthesis: This compound acts as a valuable building block in the synthesis of peptides, allowing researchers to create specific sequences with enhanced stability and reactivity.

Drug Development: It plays a crucial role in the pharmaceutical industry for developing new drug candidates, particularly in creating prodrugs that improve bioavailability and target delivery.

Bioconjugation: The chemical is used in bioconjugation processes, enabling the attachment of biomolecules to surfaces or other molecules, which is essential for developing diagnostic tools and targeted therapies.

Protein Modification: It facilitates the modification of proteins, enhancing their properties for research applications, such as improving solubility or stability in various environments.

Research in Neuroscience: This compound is utilized in studies related to neurotransmitter pathways, helping researchers understand the role of phenylalanine derivatives in brain function and disorders.

References

Synthesis of a highly thermostable insulin by phenylalanine conjugation at B29 Lysine

Publication Name: Communications Chemistry
Publication Date: 2024-07-23
DOI: 10.1038/s42004-024-01241-z

Chemoproteomic Profiling of Adenylation Domain Functions in Gramicidin S-Producing Non-ribosomal Peptide Synthetases

Publication Name: Non-Ribosomal Peptide Biosynthesis and Engineering
Publication Date: 2023
DOI: 10.1007/978-1-0716-3214-7_4

The synthesis and properties of mitochondrial targeted iron chelators

Publication Name: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Publication Date: 2022-04-02
DOI: 10.1007/s10534-022-00383-8

Affinity Purification Method for the Identification of Nonribosomal Peptide Biosynthetic Enzymes Using a Synthetic Probe for Adenylation Domains

Publication Name: Nonribosomal Peptide and Polyketide Biosynthesis
Publication Date: 2016
DOI: 10.1007/978-1-4939-3375-4_4