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Sku CI02650_1_G
Chem Impex
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Product Information

Product Name
Fmoc-N-methyl-L-alanine
Brand Name
Chem Impex
Product Number
02650
CAS
84000-07-7
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
688634
IUPAC Name
(2S)-2-9H-fluoren-9-ylmethoxycarbonyl(methyl)aminopropanoic acid
InChI Key
JOFHWKQIQLPZTC-LBPRGKRZSA-N
SMILES
CC@@H(C(=O)O)N(C)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Description

Fmoc-N-methyl-L-alanine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the introduction of N-methylation, which can enhance the stability and bioactivity of the resulting peptides.

Drug Development: Researchers use Fmoc-N-methyl-L-alanine in the development of pharmaceutical compounds, particularly in creating more effective drug candidates with improved pharmacological properties.

Bioconjugation: It plays a significant role in bioconjugation processes, where it can be used to attach biomolecules to drugs or imaging agents, enhancing their targeting capabilities in therapeutic applications.

Protein Engineering: This compound is instrumental in protein engineering, enabling scientists to modify proteins for better functionality, stability, or specificity in various applications, including diagnostics and therapeutics.

Research in Neuroscience: Fmoc-N-methyl-L-alanine is also explored in neuroscience research, where it may be used to study the effects of methylation on neurotransmitter activity and receptor interactions.

References Data Source From Pubchem

Coupling Using HATU/N,N-Diisopropylethylamine

Publication Name: Science of Synthesis
Publication Date: 2024

Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor

Publication Name: Journal of Flow Chemistry
Publication Date: 2018-02-23
DOI: 10.1007/s41981-018-0002-9

Structure and Synthesis of Conformationally Constrained Molecules Containing Piperazic Acid

Publication Name: Topics in Heterocyclic Chemistry
Publication Date: 2015
DOI: 10.1007/7081_2015_185