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Chem Impex
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Product Information

Product Name
Na-Fmoc-D-tryptophan
Brand Name
Chem Impex
Product Number
02462
CAS
86123-11-7
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
978344
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoic acid
InChI Key
MGHMWKZOLAAOTD-XMMPIXPASA-N
SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC@H(CC4=CNC5=CC=CC=C54)C(=O)O

Description

Na-Fmoc-D-tryptophan is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of D-tryptophan residues into peptides.

Drug Development: Its role in medicinal chemistry is significant, as it can be used to design and develop novel therapeutic agents, especially those targeting neurological disorders due to tryptophan's involvement in serotonin production.

Biotechnology: In the field of biotechnology, it is utilized to create modified proteins that can enhance enzyme activity or stability, making it valuable for industrial applications.

Research on Neurotransmitters: This compound aids in studying the effects of tryptophan on neurotransmitter levels, which is crucial for understanding mood disorders and developing antidepressant therapies.

Fluorescent Labeling: Na-Fmoc-D-tryptophan can be used in the development of fluorescent probes, which are essential for tracking biological processes in live cells, providing insights into cellular functions.

References Data Source From Pubchem

Experimental

Publication Name: Total Synthesis of Natural Products with Antimicrobial Activity
Publication Date: 2018
DOI: 10.1007/978-981-10-8806-3_5

Total Synthesis of Skyllamycins A–C

Publication Name: Total Synthesis of Natural Products with Antimicrobial Activity
Publication Date: 2018
DOI: 10.1007/978-981-10-8806-3_4

Fast and economical SPPS-solution, Boc-Fmoc combination synthesis of a cyclic endothelin antagonist: Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp)

Publication Name: Peptides 1994
Publication Date: 1995
DOI: 10.1007/978-94-011-1468-4_128

A recombinant human stromelysin catalytic domain identifying tryptophan derivatives as human stromelysin inhibitors

Publication Name: Journal of Medicinal Chemistry
Publication Date: 1994-01-07
DOI: 10.1021/jm00027a027