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Product Information

Product Name
Fmoc-4-nitro-L-phenylalanine
Brand Name
Chem Impex
Product Number
02447
CAS
95753-55-2
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
7016054
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-nitrophenyl)propanoic acid
InChI Key
RZRRJPNDKJOLHI-QFIPXVFZSA-N
SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC@@H(CC4=CC=C(C=C4)N+(=O)O-)C(=O)O

Application

Fmoc-4-nitro-L-phenylalanine is widely utilized in research focused on

Peptide Synthesis: This compound serves as a key building block in solid-phase peptide synthesis, allowing researchers to create complex peptides with specific sequences for various applications in biochemistry and pharmacology.

Drug Development: Its unique properties make it valuable in the development of novel therapeutic agents, particularly in targeting specific biological pathways, enhancing drug efficacy.

Bioconjugation: Fmoc-4-nitro-L-phenylalanine can be used in bioconjugation processes, facilitating the attachment of biomolecules to drugs or imaging agents for improved delivery and targeting in medical applications.

Fluorescent Probes: Researchers utilize this compound to develop fluorescent probes for studying protein interactions and cellular processes, providing insights into complex biological systems.

Research in Cancer Therapeutics: Its application in cancer research is notable, as it aids in the design of peptide-based inhibitors that can selectively target cancer cells, potentially leading to more effective treatments.

References

Hierarchically oriented organization in supramolecular peptide crystals

Publication Name: Protein and peptide letters
Publication Date: 2019-09-10
DOI: 10.1038/s41570-019-0129-8

The best and the brightest: exploiting tryptophan-sensitized Tb(3+) luminescence to engineer lanthanide-binding tags

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2015
DOI: 10.1007/978-1-4939-2020-4_14

Generation of Narrowband Ultrashort Pulses Tunable in the mid-IR and the Application to Vibrational Energy Transfer in a Modified Amino Acid

Publication Name: Springer Series in Chemical Physics
Publication Date: 2009
DOI: 10.1007/978-3-540-95946-5_105

Chemical Synthesis of the Aspartic Proteinase from Human Immunodeficiency Virus (HIV)

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 1994
DOI: 10.1385/0-89603-274-4:287