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Chem Impex
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Product Information

Product Name
Z-L-phenylalanine-chloromethylketone
Brand Name
Chem Impex
Product Number
02227
CAS
26049-94-5
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
99625
IUPAC Name
benzyl N-(2S)-4-chloro-3-oxo-1-phenylbutan-2-ylcarbamate
InChI Key
OYHLRJGDELITAF-INIZCTEOSA-N
SMILES
C1=CC=C(C=C1)CC@@H(C(=O)CCl)NC(=O)OCC2=CC=CC=C2

Application

Z-L-phenylalanine-chloromethylketone is widely utilized in research focused on:

Protein Synthesis Inhibition: This compound is effective in studying protein synthesis pathways, particularly in cancer research, by selectively inhibiting specific enzymes involved in the process.

Drug Development: It serves as a valuable tool in the development of new pharmaceuticals, particularly in designing inhibitors for various biological targets, enhancing the efficacy of drug candidates.

Neuroscience Research: Researchers use it to investigate neurotransmitter systems, helping to understand conditions like depression and anxiety, and to explore potential therapeutic interventions.

Biochemical Assays: The compound is employed in various biochemical assays to measure enzyme activity, providing insights into metabolic pathways and disease mechanisms.

Peptide Synthesis: It plays a crucial role in peptide synthesis, allowing for the creation of modified peptides that can be used in therapeutic applications, improving specificity and potency.

References

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells

Publication Name: Biochemical and Biophysical Research Communications
Publication Date: 2023-10-30
DOI: 10.1016/j.bbrc.2023.08.050

Target Class Profiling of Small-Molecule Methyltransferases

Publication Name: ACS Chemical Biology
Publication Date: 2023-03-28
DOI: 10.1021/acschembio.3c00124

A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2

Publication Name: The Journal of biological chemistry
Publication Date: 2022-08
DOI: 10.1016/j.jbc.2022.102228

Perspectives on SARS-CoV-2 Main Protease Inhibitors

Publication Name: Journal of Medicinal Chemistry
Publication Date: 2021-11-19
DOI: 10.1021/acs.jmedchem.1c00409

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

Publication Name: Cell Reports
Publication Date: 2021-04-27
DOI: 10.1016/j.celrep.2021.109040