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Chem Impex
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Product Information

Product Name
N2-Isobutyrylguanosine
Brand Name
Chem Impex
Product Number
00879
CAS
64350-24-9
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
135722152
IUPAC Name
N-9-(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl-6-oxo-1H-purin-2-yl-2-methylpropanamide
InChI Key
OXTYJSXVUGJSGM-HTVVRFAVSA-N
SMILES
CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C@H3C@@H(C@@H(C@H(O3)CO)O)O

Application

N2-Isobutyrylguanosine is widely utilized in research focused on:

Pharmaceutical Development: This compound is explored for its potential in developing new antiviral and anticancer drugs, leveraging its unique structure to target specific biological pathways.

Biochemical Research: It serves as a valuable tool for studying nucleotide metabolism and signaling pathways, enabling researchers to better understand cellular processes.

Gene Expression Studies: N2-Isobutyrylguanosine is used to investigate the regulation of gene expression, particularly in the context of RNA modifications, which can lead to breakthroughs in genetic therapies.

Diagnostic Applications: Its role in cellular signaling makes it a candidate for developing diagnostic tools that can detect specific diseases based on nucleotide alterations.

Drug Delivery Systems: Researchers are exploring its use in creating novel drug delivery systems that enhance the bioavailability and efficacy of therapeutic agents.

References

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Publication Name: Nature Biotechnology
Publication Date: 2022-06-02
DOI: 10.1038/s41587-022-01334-x

Discovery of anti-influenza nucleoside triphosphates targeting the catalytic site of A/PR/8/34/H1N1 polymerase

Publication Name: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents
Publication Date: 2020-05-24
DOI: 10.1007/s00044-020-02561-0

New tools in nucleoside toolbox of tick-borne encephalitis virus reproduction inhibitors

Publication Name: Bioorganic & Medicinal Chemistry Letters
Publication Date: 2017-03-01
DOI: 10.1016/j.bmcl.2017.01.040

Light-controlled gene silencing in zebrafish embryos

Publication Name: Nature Chemical Biology
Publication Date: 2007-08-23
DOI: 10.1038/nchembio.2007.30