NH2-Pluronic F127-NH2, 95%

Product Introduction

NH₂-Pluronic F127-NH₂ (Amine-Terminated Pluronic F127) is a functionalized amphiphilic block copolymer derived from Pluronic F127, featuring amino groups at both polymer termini for further conjugation and surface modification.

With excellent biocompatibility, thermoresponsive behavior, and versatile functionalization capability, NH₂-Pluronic F127-NH₂ is widely investigated as a multifunctional biomaterial for:

• Drug delivery systems
• Injectable thermosensitive hydrogels
• Nanocarrier development
• Tissue engineering scaffolds
• Biomedical surface modification

Pluronic F127 is an FDA-approved polymer with established safety profiles, making F127-based materials attractive candidates for advanced biomedical research.

Key Features and Benefits

1. Thermoresponsive Drug Delivery Platform

NH₂-Pluronic F127-NH₂ exhibits reversible temperature-dependent phase transition behavior:

• Sol state: approximately 20°C
• Gel state: approximately 37°C

This thermoresponsive property enables the formation of in situ hydrogels at physiological temperature, providing controlled and sustained drug release platforms.

The phase transition temperature can be adjusted by modifying the PEO/PPO block composition, allowing customization for different biomedical applications.

2. Enhanced Drug Encapsulation and Delivery Performance

At physiological temperature (37°C), NH₂-Pluronic F127-NH₂ can self-assemble into 20–100 nm core-shell micellar structures, providing a hydrophobic core for encapsulating poorly water-soluble compounds.

Typical advantages include:

• Improved solubility of hydrophobic molecules such as paclitaxel.
• Drug loading capacity of approximately 15–20% (w/w) in optimized systems.
• Low critical micelle concentration (CMC: 0.001–0.1 mg/mL) to maintain micellar stability under dilution conditions.

These characteristics make NH₂-Pluronic F127-NH₂ suitable for research involving nanoparticle-based drug delivery and controlled release systems.

3. Tissue Engineering and Regenerative Medicine Applications

The terminal amino groups provide reactive sites for biomolecule conjugation and scaffold modification.

Potential advantages include:

• Amino group density: 5–10 mmol/g
• RGD peptide conjugation for enhanced cell adhesion studies
• Three-dimensional porous hydrogel structures (porosity >90%) supporting nutrient diffusion and cell growth

NH₂-Pluronic F127-NH₂-based scaffolds are widely studied in tissue engineering, including bone regeneration and cell culture applications.

4. Biocompatibility and Biosafety Profile

NH₂-Pluronic F127-NH₂ inherits the excellent biocompatibility characteristics of Pluronic F127.

Reported evaluation results include:

• Cytotoxicity grade: 0
• Hemolysis rate: <1%
• Biodegradation observed after implantation studies

The hydrophilic PEO segment helps reduce nonspecific protein adsorption and improves circulation stability, supporting its use in biomedical delivery research.

5. Flexible Chemical Modification Capability

The terminal amino groups enable further functionalization through standard bioconjugation chemistry.

Common modification strategies include:

Fluorescent Labeling

• FITC conjugation efficiency: >95%

Targeting Modification

• Folic acid and other ligand conjugation for targeted delivery research

Crosslinking Modification

• NHS ester-based crosslinking for improved hydrogel mechanical properties

This modular design enables the development of multifunctional biomaterials and drug-device combination research platforms.

Applications

NH₂-Pluronic F127-NH₂ is commonly used in:

Drug Delivery Research

• Hydrophobic drug encapsulation
• Nanomicelle formulation
• Controlled release systems
• Injectable drug delivery hydrogels

Biomedical Materials

• Thermosensitive hydrogel preparation
• Tissue engineering scaffolds
• Cell culture matrices

Bioconjugation and Functional Materials

• Fluorescent labeling
• Targeting ligand modification
• Biomolecule immobilization

Pharmaceutical Research

• Nanomedicine development
• Drug formulation optimization
• Advanced biomaterial platforms

Why Choose NH₂-Pluronic F127-NH₂?

• FDA-approved F127 backbone with established biocompatibility
• Dual amino functionalization for versatile chemical modification
• Thermosensitive hydrogel formation at physiological temperature
• Excellent potential for drug delivery and tissue engineering research
• Consistent polymer quality for laboratory and industrial research applications

Q1: What is NH₂-Pluronic F127-NH₂ used for?

A: NH₂-Pluronic F127-NH₂ is mainly used in biomedical research, including thermosensitive hydrogel preparation, drug delivery systems, nanocarrier development, tissue engineering, and biomolecule conjugation studies.

Q2: What is the advantage of amino-functionalized Pluronic F127?

A: The terminal amino groups provide reactive sites for further chemical modification, enabling fluorescent labeling, targeting ligand conjugation, and crosslinking with other biomolecules or polymers.

Q3: Is NH₂-Pluronic F127-NH₂ suitable for drug delivery research?

A: Yes. Its amphiphilic structure, micelle-forming ability, and temperature-responsive gelation behavior make it a valuable material for controlled drug delivery and formulation research.

Q4: What is the storage condition of NH₂-Pluronic F127-NH₂?

A: Store according to the product specification provided with the batch. Protect from moisture and keep under recommended temperature conditions to maintain material stability.