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(S)-6-[(1-Acetylpiperidin-4-yl)amino]-N-[3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide, 98%|9128426|1616392-22-3

(S)-6-[(1-Acetylpiperidin-4-yl)amino]-N-[3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide, 98%

Cat. No JK9128426_1_G
J&K Chemical

Product Information

Product Name
(S)-6-(1-Acetylpiperidin-4-yl)amino-N-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropylpyrimidine-4-carboxamide, 98%
Brand Name
J&K
Product Number
9128426
CAS
1616392-22-3
Molecular Formula
C24H32N6O3
Molecular Weight
452.55
Certificate of Analysis (COA)​
COA not found

General Information

Synonyms
GSK3326595
PubChem CID
90241742
IUPAC Name
6-(1-acetylpiperidin-4-yl)amino-N-(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropylpyrimidine-4-carboxamide
InChI Key
JLCCNYVTIWRPIZ-NRFANRHFSA-N
SMILES
CC(=O)N1CCC(CC1)NC2=NC=NC(=C2)C(=O)NCC@@H(CN3CCC4=CC=CC=C4C3)O

Properties

Density
1.275
Boiling Point
760.3

Safety Information

Storage Condition
Freezer -20℃

References Data Source From Pubchem

MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design
Publication Name: Journal of Medicinal Chemistry
Publication Date: 2025-02-07
DOI: 10.1021/acs.jmedchem.4c01998

Design, Synthesis, and Biological Evaluation of 3,4-Dihydroisoquinolin-1(2H)-one Derivatives as Protein Arginine Methyltransferase 5 Inhibitors for the Treatment of Non-Hodgkin’s Lymphoma
Publication Name: Journal of Medicinal Chemistry
Publication Date: 2024-12-26
DOI: 10.1021/acs.jmedchem.4c01548

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer
Publication Name: Science Translational Medicine
Publication Date: 2023-06-21
DOI: 10.1126/scitranslmed.add7872

Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors in Oncology Clinical Trials: A review
Publication Name: Journal of Immunotherapy and Precision Oncology
Publication Date: 2022-06-22
DOI: 10.36401/jipo-22-1

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers
Publication Name: Journal of Medicinal Chemistry
Publication Date: 2022-01-18
DOI: 10.1021/acs.jmedchem.1c01900

(S)-6-[(1-Acetylpiperidin-4-yl)amino]-N-[3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide, 98%

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