Torin 2, 98%, an mTOR inhibitor

Name: Torin 2, 98%, an mTOR inhibitor | 1223001-51-1
Brand: J&K Chemical
SKU: JK901580_5_MG
Price: 91.2 USD
Availability: InStock

Cat. No JK901580_5_MG

Vendor: J&K Chemical

Product Information

Product Name

Torin 2, 98%, an mTOR inhibitor

Brand Name

J&K

Product Number

901580

CAS

1223001-51-1

SDS Document

View/Download

Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

51358113

IUPAC Name

9-(6-amino-3-pyridinyl)-1-3-(trifluoromethyl)phenylbenzoh1,6naphthyridin-2-one

InChI Key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

SMILES

C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F

Safety Information

Storage Condition

Freezer -20℃

References Data Source From Pubchem

PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1

Publication Name: Biochemical Pharmacology

Publication Date: 2024-12

DOI: 10.1016/j.bcp.2024.116620

Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors

Publication Name: Bioorganic & Medicinal Chemistry

Publication Date: 2024-01-15

DOI: 10.1016/j.bmc.2023.117561

Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates

Publication Name: Frontiers in Pharmacology

Publication Date: 2023-12-01

DOI: 10.3389/fphar.2023.1291246

Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma

Publication Name: Cancer Letters

Publication Date: 2023-08-01

DOI: 10.1016/j.canlet.2023.216284

Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening

Publication Name: Journal of Medicinal Chemistry

Publication Date: 2023-07-13

DOI: 10.1021/acs.jmedchem.3c00082

Torin 2, 98%, an mTOR inhibitor

Product Information

General Information

Safety Information

References Data Source From Pubchem

PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1

Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors

Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates

Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma

Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening