Lapatinib ditosylate, 98%, a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively

Name: Lapatinib ditosylate, 98%, a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively | 388082-77-7
Brand: J&K Chemical
SKU: JK795123_5_MG
Price: 268.0 USD
Availability: InStock

Cat. No JK795123_5_MG

Vendor: J&K Chemical

Product Information

Product Name

Lapatinib ditosylate, 98%, a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively

Brand Name

J&K

Product Number

795123

CAS

388082-77-7

Molecular Formula

C43H42ClFN4O10S3

Molecular Weight

925.46

Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

9941095

IUPAC Name

N-3-chloro-4-(3-fluorophenyl)methoxyphenyl-6-5-(2-methylsulfonylethylamino)methylfuran-2-ylquinazolin-4-amine;bis(4-methylbenzenesulfonic acid)

InChI Key

UWYXLGUQQFPJRI-UHFFFAOYSA-N

SMILES

CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

Safety Information

Precautionary Statement

P262

References Data Source From Pubchem

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors

Publication Name: European Journal of Medicinal Chemistry

Publication Date: 2018-07-15

DOI: 10.1016/j.ejmech.2018.06.011

Lapatinib ditosylate, 98%, a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively

Product Information

General Information

Safety Information

References Data Source From Pubchem

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors