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Rolipram, 97%, a PDE4 inhibitor|280414|61413-54-5

Rolipram, 97%, a PDE4 inhibitor

Cat. No JK280414_50_MG
J&K Chemical

Product Information

Product Name
Rolipram, 97%, a PDE4 inhibitor
Brand Name
J&K
Product Number
280414
CAS
61413-54-5
Molecular Formula
C16H21NO3
Molecular Weight
275.35
Certificate of Analysis (COA)​
COA not found

General Information

Synonyms
4-3-(Cyclopentyloxy)-4-methoxyphenyl-2-pyrrolidinone
PubChem CID
5092
IUPAC Name
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
InChI Key
HJORMJIFDVBMOB-UHFFFAOYSA-N
SMILES
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

Properties

Melting Point
130.0-134.0

Safety Information

GHS Symbols
Hazard Symbol
Signal Word
Warning
Hazard Statement
H315
H319
H335
Precautionary Statement
P280
P321
P261
P271
P319
P405
P501
P302+P352
P332+P317
P362+P364
P264+P265
P305+P351+P338
P337+P317
P304+P340
P403+P233
Storage Condition
Freezer -20℃

References Data Source From Pubchem

Roflumilast Elicits Therapeutic and Neuroprotective Effects in 3-Nitropropionic Acid-Induced Huntington’s Disease-Like Neurodegeneration in Rats by Mitigating NLRP3 Inflammasome-Mediated Pyroptosis, Ferroptosis, and Glial Activation
Publication Name: Neurochemical Research
Publication Date: 2026-02-28
DOI: 10.1007/s11064-026-04682-1

Phosphodiesterase-4 Inhibitors in Chronic Obstructive Pulmonary Disease: Molecular Mechanisms, Current Therapeutics, and Future Perspectives
Publication Name: Cell Biochemistry and Biophysics
Publication Date: 2026-02-25
DOI: 10.1007/s12013-026-02031-1

Phosphodiesterase signaling in asthma: mechanistic insights and emerging therapeutic strategies
Publication Name: Naunyn-Schmiedeberg's Archives of Pharmacology
Publication Date: 2026-02-17
DOI: 10.1007/s00210-026-05098-y

PDE4 inhibitor rolipram dynamically regulates the balance between D1-MSNs and D2-MSNs in the DMS to modulate abnormal “Go” behavior associated with alcohol addiction
Publication Name: Acta Pharmacologica Sinica
Publication Date: 2026-02-06
DOI: 10.1038/s41401-025-01738-w

Dystonia: Insights into Mechanisms and Novel Therapeutics
Publication Name: Current Neurology and Neuroscience Reports
Publication Date: 2026-01-10
DOI: 10.1007/s11910-025-01479-7

Rolipram, 97%, a PDE4 inhibitor

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