Product Introduction

Sodium 1-Heptanesulfonate (CAS No. 22767-50-6) is a high-purity alkyl sulfonate ion-pair reagent widely used in analytical chemistry, especially in ion-pair high-performance liquid chromatography (HPLC).

As a strong ionic surfactant-like compound containing a hydrophobic heptyl chain and a sulfonate group, Sodium 1-Heptanesulfonate can form ion pairs with positively charged analytes, improving retention, selectivity, and separation efficiency in reversed-phase HPLC.

It is commonly applied in pharmaceutical analysis, biochemical analysis, impurity testing, and chromatographic method development due to its excellent solubility, stability, and reproducible chromatographic performance.

Structural Characteristics

Sulfonate Group (-SO₃⁻)

The sulfonate group provides:

• Strong ionic character
• Excellent aqueous solubility
• Stable interaction with charged molecules
• Compatibility with chromatographic systems

Heptyl Alkyl Chain

The seven-carbon hydrophobic chain contributes:

• Hydrophobic interaction with analytes
• Increased retention in reversed-phase chromatography
• Improved separation of ionic compounds

Compared with shorter-chain sulfonates, Sodium 1-Heptanesulfonate provides stronger hydrophobic interaction.

Key Research Applications

1. Ion-Pair HPLC Analysis

Sodium 1-Heptanesulfonate is primarily used as an ion-pair chromatography reagent.

Applications include:

• Separation of basic compounds
• Pharmaceutical impurity analysis
• API assay development
• HPLC method optimization
• Quality control testing

It improves chromatographic retention by forming ion pairs with positively charged analytes.

2. Pharmaceutical Analysis

Used extensively in pharmaceutical analytical workflows.

Applications include:

• Drug substance analysis
• Basic pharmaceutical compound separation
• Stability testing
• Related substance determination
• Quality control methods

3. Biochemical Molecule Separation

Sodium 1-Heptanesulfonate supports chromatographic analysis of biological molecules.

Applications include:

• Amino acid analysis
• Peptide separation
• Biogenic amine detection
• Metabolite analysis

4. Analytical Method Development

Used for optimizing chromatographic conditions.

Applications include:

• Reversed-phase HPLC development
• Retention mechanism studies
• Selectivity adjustment
• Mobile phase optimization

5. Electrochemical and Surface Chemistry Research

Sulfonate salts are also investigated in ionic systems.

Applications include:

• Electrolyte studies
• Ion transport research
• Surface interaction studies
• Ionic environment regulation

Advantages

• High chromatographic purity
• Excellent water solubility
• Stable ion-pairing performance
• Suitable for HPLC method development
• Improves separation of ionic compounds
• Widely validated analytical reagent

Storage & Handling

• Store in a cool, dry place.
• Keep container tightly sealed.
• Protect from moisture.
• Avoid contamination during handling.

Research Areas

• Analytical chemistry
• Pharmaceutical quality control
• HPLC method development
• Separation science
• Biochemical analysis
• Electrochemical research

Q1: What is Sodium 1-Heptanesulfonate?

A: Sodium 1-Heptanesulfonate (CAS No. 22767-50-6) is an alkyl sulfonate salt mainly used as an ion-pair reagent for HPLC analysis.

Q2: What is Sodium 1-Heptanesulfonate used for?

A: It is mainly used for:

• Ion-pair chromatography
• Pharmaceutical analysis
• Separation of basic compounds
• Analytical method development

Q3: Why is Sodium 1-Heptanesulfonate used in HPLC?

A: It forms ion pairs with positively charged analytes, modifying their interaction with the stationary phase and improving chromatographic separation.

Q4: What compounds can be analyzed using Sodium 1-Heptanesulfonate?

A: It is commonly used for:

• Basic drugs
• Amines
• Peptides
• Ionic organic compounds
• Polar metabolites

Q5: What is the difference between Sodium Pentanesulfonate and Sodium Heptanesulfonate?

Q6: Is Sodium 1-Heptanesulfonate a buffer?

A: No. It is mainly an ion-pair chromatography reagent, not a conventional buffer.

Q7: Can Sodium 1-Heptanesulfonate be used for LC-MS?

A: It is mainly used in HPLC-UV and conventional liquid chromatography. Ion-pair reagents may require optimization for LC-MS due to possible ion suppression effects.

Q8: How should Sodium 1-Heptanesulfonate be stored?

A: Store it in a sealed container under dry conditions at room temperature and protect it from moisture.