BMS-687453, 99%, a potent and selective PPARα agonist

Name: BMS-687453, 99%, a potent and selective PPARα agonist | 1000998-59-3
Brand: J&K Chemical
SKU: JK2286522_10_MG
Price: 205.2 USD
Availability: OutOfStock

Cat. No JK2286522_10_MG

Vendor: J&K Chemical

Product Information

Product Name

BMS-687453, 99%, a potent and selective PPARα agonist

Brand Name

J&K

Product Number

2286522

CAS

1000998-59-3

SDS Document

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Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

16725047

IUPAC Name

2-3-2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-ylmethoxyphenylmethyl-methoxycarbonylaminoacetic acid

InChI Key

UJIBXDMNCMEJAY-UHFFFAOYSA-N

SMILES

CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC=CC(=C3)CN(CC(=O)O)C(=O)OC

Safety Information

Storage Condition

Freezer -20℃

References

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer

Publication Name: Science Translational Medicine

Publication Date: 2023-06-21

DOI: 10.1126/scitranslmed.add7872

High-Throughput Screening to Identify Inhibitors of the Type I Interferon–Major Histocompatibility Complex Class I Pathway in Skeletal Muscle

Publication Name: ACS Chemical Biology

Publication Date: 2020-05-27

DOI: 10.1021/acschembio.0c00343

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist

Publication Name: ACS Medicinal Chemistry Letters

Publication Date: 2016-04-14

DOI: 10.1021/acsmedchemlett.6b00033

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation

Publication Name: Bioorganic & Medicinal Chemistry Letters

Publication Date: 2010-05-01

DOI: 10.1016/j.bmcl.2010.03.019

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)

Publication Name: Journal of Medicinal Chemistry

Publication Date: 2010-04-08

DOI: 10.1021/jm9016812

BMS-687453, 99%, a potent and selective PPARα agonist

Product Information

General Information

Safety Information

References

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer

High-Throughput Screening to Identify Inhibitors of the Type I Interferon–Major Histocompatibility Complex Class I Pathway in Skeletal Muscle

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)