Product Introduction

Bilirubin Conjugate (Disodium Salt, CAS No. 68683-34-1) is a water-soluble bilirubin derivative formed by conjugation of bilirubin with taurine groups. Unlike unconjugated bilirubin, this conjugated form exhibits improved aqueous solubility, making it an important biochemical reagent for studying bilirubin metabolism, liver function, bile pigment transport, and oxidative stress mechanisms.

Bilirubin conjugates are naturally occurring intermediates in mammalian bilirubin metabolism, where bilirubin is converted into more water-soluble forms before excretion through bile.

Due to its structural similarity to physiological bilirubin metabolites, Bilirubin Conjugate Disodium Salt is widely used in biochemistry, clinical chemistry, hepatology research, analytical assay development, and antioxidant mechanism studies.

Structural Characteristics

Bilirubin Tetrapyrrole Core

The bilirubin backbone provides:

• Natural bile pigment characteristics
• Conjugated π-electron system
• Antioxidant activity
• Biological relevance in metabolism studies

Taurine Conjugated Groups

The sulfonated taurine groups contribute:

• Increased water solubility
• Improved biological compatibility
• Ionic stability
• Easier handling in aqueous systems

Disodium Salt Form

The sodium salt structure provides:

• Enhanced solubility
• Stable ionic form
• Compatibility with biochemical assays

Key Research Applications

1. Bilirubin Metabolism Research

Bilirubin conjugate is an important tool for studying bilirubin pathways.

Applications include:

• Hepatic bilirubin metabolism studies
• Bilirubin transport research
• Bile pigment pathway analysis
• Liver disease mechanism studies

2. Clinical Chemistry Research

Used as a reference compound in bilirubin-related assays.

Applications include:

• Bilirubin detection method development
• Clinical chemistry assay validation
• Analytical standard preparation
• Diagnostic reagent research

3. Liver Function and Hepatology Studies

Bilirubin conjugates support research into liver physiology.

Applications include:

• Hepatocyte function studies
• Cholestasis research
• Drug-induced liver injury models
• Hepatic transport studies

4. Oxidative Stress and Antioxidant Research

Bilirubin derivatives are investigated for antioxidant mechanisms.

Applications include:

• Reactive oxygen species (ROS) studies
• Oxidative stress pathways
• Antioxidant activity evaluation
• Cellular protection mechanisms

5. Transport Protein and Binding Studies

Used for investigating bilirubin-related molecular interactions.

Applications include:

• Protein–bilirubin interaction studies
• Transporter research
• Biomolecule binding analysis
• Molecular mechanism studies

Advantages

• Water-soluble bilirubin derivative
• Biologically relevant metabolite
• Suitable for bilirubin pathway studies
• Useful reference material for analytical research
• Applicable in liver and metabolic research

Storage & Handling

• Store in a cool place.
• Keep container tightly closed in a dry and well-ventilated place.
• Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Research Areas

• Biochemistry
• Clinical chemistry
• Hepatology
• Metabolism research
• Oxidative stress biology
• Analytical chemistry
• Biomedical research

Q1: What is Bilirubin Conjugate Disodium Salt?

A: Bilirubin Conjugate Disodium Salt (CAS No. 68683-34-1) is a water-soluble bilirubin derivative used for studying bilirubin metabolism and related biochemical pathways.

Q2: What is CAS 68683-34-1 used for?

A: It is mainly used in:

• Bilirubin metabolism research
• Liver function studies
• Clinical chemistry assays
• Oxidative stress research

Q3: What is the difference between bilirubin and bilirubin conjugate?

Q4: Why is bilirubin conjugation important?

A: Conjugation increases bilirubin water solubility, allowing transport through bile and elimination from the body.

Q5: Is Bilirubin Conjugate used in clinical testing?

A: It is mainly used as a research reagent and analytical reference compound for bilirubin-related assays.

Q6: Can Bilirubin Conjugate be used in antioxidant studies?

A: Yes. Bilirubin-related molecules are studied for their ability to participate in antioxidant defense mechanisms.

Q7: How should Bilirubin Conjugate be stored?

A: Store at -20°C and protect from light to maintain chemical stability.

Q8: Is Bilirubin Conjugate water soluble?

A: Yes. Compared with unconjugated bilirubin, the conjugated disodium salt form has significantly improved water solubility.