WZ4003, 97%, a first potent and highly specific NUAK kinase inhibitor

Name: WZ4003, 97%, a first potent and highly specific NUAK kinase inhibitor | 1214265-58-3
Brand: J&K Chemical
SKU: JK1835021_5_MG
Price: 89.3 USD
Availability: OutOfStock

Cat. No JK1835021_5_MG

Vendor: J&K Chemical

Product Information

Product Name

WZ4003, 97%, a first potent and highly specific NUAK kinase inhibitor

Brand Name

J&K

Product Number

1835021

CAS

1214265-58-3

SDS Document

View/Download

Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

72200024

IUPAC Name

N-3-5-chloro-2-2-methoxy-4-(4-methylpiperazin-1-yl)anilinopyrimidin-4-yloxyphenylpropanamide

InChI Key

SDGJBAUIGHSMRI-UHFFFAOYSA-N

SMILES

CCC(=O)NC1=CC(=CC=C1)OC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)C)OC

Safety Information

Storage Condition

Freezer -20℃

References Data Source From Pubchem

Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors

Publication Name: Bioorganic & Medicinal Chemistry

Publication Date: 2024-01-15

DOI: 10.1016/j.bmc.2023.117561

p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003

Publication Name: Acta Neuropathologica

Publication Date: 2024-01-04

DOI: 10.1007/s00401-023-02667-w

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer

Publication Name: Science Translational Medicine

Publication Date: 2023-06-21

DOI: 10.1126/scitranslmed.add7872

Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer

Publication Name: European Journal of Medicinal Chemistry

Publication Date: 2021-01-15

DOI: 10.1016/j.ejmech.2020.113080

Development and Therapeutic Potential of NUAKs Inhibitors

Publication Name: Journal of Medicinal Chemistry

Publication Date: 2020-12-24

DOI: 10.1021/acs.jmedchem.0c00533

WZ4003, 97%, a first potent and highly specific NUAK kinase inhibitor

Product Information

General Information

Safety Information

References Data Source From Pubchem

Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors

p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer

Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer

Development and Therapeutic Potential of NUAKs Inhibitors